TCMID


29106634	TCMID 2.0: a comprehensive resource for TCM. [PMID: 29106634] Huang L, Xie D, Yu Y, Liu H, Shi Y, Shi T, Wen C. Abstract As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, Traditional Chinese Medicine (TCM) is capturing worldwide attention in life science field. Traditional Chinese Medicine Integrated Database (TCMID), which was originally launched in 2013, was a comprehensive database aiming at TCM's modernization and standardization. It has been highly recognized among pharmacologists and scholars in TCM researches. The latest release, TCMID 2.0 (http://www.megabionet.org/tcmid/), replenished the preceding database with 18 203 herbal ingredients, 15 prescriptions, 82 related targets, 1356 drugs, 842 diseases and numerous new connections between them. Considering that chemical changes might take place in decocting process of prescriptions, which may result in new ingredients, new data containing the prescription ingredients was collected in current version. In addition, 778 herbal mass spectrometry (MS) spectra related to 170 herbs were appended to show the variation of herbal quality in different origin and distinguish genuine medicinal materials from common ones while 3895 MS spectra of 729 ingredients were added as the supplementary materials of component identification. With the significant increase of data, TCMID 2.0 will further facilitate TCM's modernization and enhance the exploration of underlying biological processes that are response to the diverse pharmacologic actions of TCM. Nucleic Acids Res. 2018:46(D1) \| 173 Citations (from Europe PMC, 2025-03-22)
23203875	TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. [PMID: 23203875] Xue R, Fang Z, Zhang M, Yi Z, Wen C, Shi T. Abstract As an alternative to modern western medicine, Traditional Chinese Medicine (TCM) is receiving increasingly attention worldwide. Great efforts have been paid to TCM's modernization, which tries to bridge the gap between TCM and modern western medicine. As TCM and modern western medicine share a common aspect at molecular level that the compound(s) perturb human's dysfunction network and restore human normal physiological condition, the relationship between compounds (in herb, refer to ingredients) and their targets (proteins) should be the key factor to connect TCM and modern medicine. Accordingly, we construct this Traditional Chinese Medicine Integrated Database (TCMID, http://www.megabionet.org/tcmid/), which records TCM-related information collected from different resources and through text-mining method. To enlarge the scope of the TCMID, the data have been linked to common drug and disease databases, including Drugbank, OMIM and PubChem. Currently, our TCMID contains ?47 000 prescriptions, 8159 herbs, 25 210 compounds, 6828 drugs, 3791 diseases and 17 521 related targets, which is the largest data set for related field. Our web-based software displays a network for integrative relationships between herbs and their treated diseases, the active ingredients and their targets, which will facilitate the study of combination therapy and understanding of the underlying mechanisms for TCM at molecular level. Nucleic Acids Res. 2013:41(Database issue) \| 293 Citations (from Europe PMC, 2025-03-22)

TCMID 2.0: a comprehensive resource for TCM. [PMID: 29106634]

Huang L, Xie D, Yu Y, Liu H, Shi Y, Shi T, Wen C.

As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, Traditional Chinese Medicine (TCM) is capturing worldwide attention in life science field. Traditional Chinese Medicine Integrated Database (TCMID), which was originally launched in 2013, was a comprehensive database aiming at TCM's modernization and standardization. It has been highly recognized among pharmacologists and scholars in TCM researches. The latest release, TCMID 2.0 (http://www.megabionet.org/tcmid/), replenished the preceding database with 18 203 herbal ingredients, 15 prescriptions, 82 related targets, 1356 drugs, 842 diseases and numerous new connections between them. Considering that chemical changes might take place in decocting process of prescriptions, which may result in new ingredients, new data containing the prescription ingredients was collected in current version. In addition, 778 herbal mass spectrometry (MS) spectra related to 170 herbs were appended to show the variation of herbal quality in different origin and distinguish genuine medicinal materials from common ones while 3895 MS spectra of 729 ingredients were added as the supplementary materials of component identification. With the significant increase of data, TCMID 2.0 will further facilitate TCM's modernization and enhance the exploration of underlying biological processes that are response to the diverse pharmacologic actions of TCM.

Nucleic Acids Res. 2018:46(D1) | 173 Citations (from Europe PMC, 2025-03-22)

TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. [PMID: 23203875]

Xue R, Fang Z, Zhang M, Yi Z, Wen C, Shi T.

Abstract

As an alternative to modern western medicine, Traditional Chinese Medicine (TCM) is receiving increasingly attention worldwide. Great efforts have been paid to TCM's modernization, which tries to bridge the gap between TCM and modern western medicine. As TCM and modern western medicine share a common aspect at molecular level that the compound(s) perturb human's dysfunction network and restore human normal physiological condition, the relationship between compounds (in herb, refer to ingredients) and their targets (proteins) should be the key factor to connect TCM and modern medicine. Accordingly, we construct this Traditional Chinese Medicine Integrated Database (TCMID, http://www.megabionet.org/tcmid/), which records TCM-related information collected from different resources and through text-mining method. To enlarge the scope of the TCMID, the data have been linked to common drug and disease databases, including Drugbank, OMIM and PubChem. Currently, our TCMID contains ?47 000 prescriptions, 8159 herbs, 25 210 compounds, 6828 drugs, 3791 diseases and 17 521 related targets, which is the largest data set for related field. Our web-based software displays a network for integrative relationships between herbs and their treated diseases, the active ingredients and their targets, which will facilitate the study of combination therapy and understanding of the underlying mechanisms for TCM at molecular level.

Nucleic Acids Res. 2013:41(Database issue) | 293 Citations (from Europe PMC, 2025-03-22)

URL:	http://www.megabionet.org/tcmid/
Full name:	Traditional Chinese Medicines Integrated Database
Description:	Traditional Chinese Medicine Integrated Database (TCMID) is a comprehensive database to provide information and bridge the gap between Traditional Chinese Medicine and modern life sciences.
Year founded:	2013
Last update:	2012-11-12
Version:	v1.0
Accessibility:	Accessible
Country/Region:	China

Data type:
Data object:
Database category:	Health and medicine
Major species:
Keywords:	traditional chinese medicine

University/Institution:	East China Normal University
Address:	Center for Bioinformatics and Computational Biology,Shanghai Key Laboratory of Regulatory Biology,The Institute of Biomedical Sciences and School of Life Science,East China Normal University,Shanghai 200241,China
City:	Shanghai
Province/State:	Shanghai
Country/Region:	China
Contact name (PI/Team):	Tieliu Shi
Contact email (PI/Helpdesk):	tieliushi01@gmail.com

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