| URL: | http://ncrnadb.scienze.univr.it/ncrnadb |
| Full name: | The non-coding RNA human interaction Data Base. |
| Description: | The ncRNA-DB project provides an integrative data base of human non-coding RNA interactions. Interactions are periodically imported from several data sources, integrated and stored in an on-line data base server. Data can be accessed by directly connecting to the server instance (OrientDB) or through a command-line interface, a Java API package and a Cytoscape 3.x App. |
| Year founded: | 2014 |
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| Accessibility: |
Unaccessible
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| Country/Region: | Italy |
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| University/Institution: | University of Catania |
| Address: | Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy |
| City: | Catania |
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| Country/Region: | Italy |
| Contact name (PI/Team): | Rosalba Giugno |
| Contact email (PI/Helpdesk): | ti.tcinu.imd@itnerivlupa |
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Comprehensive reconstruction and visualization of non-coding regulatory networks in human. [PMID: 25540777]
Research attention has been powered to understand the functional roles of non-coding RNAs (ncRNAs). Many studies have demonstrated their deregulation in cancer and other human disorders. ncRNAs are also present in extracellular human body fluids such as serum and plasma, giving them a great potential as non-invasive biomarkers. However, non-coding RNAs have been relatively recently discovered and a comprehensive database including all of them is still missing. Reconstructing and visualizing the network of ncRNAs interactions are important steps to understand their regulatory mechanism in complex systems. This work presents ncRNA-DB, a NoSQL database that integrates ncRNAs data interactions from a large number of well established on-line repositories. The interactions involve RNA, DNA, proteins, and diseases. ncRNA-DB is available at http://ncrnadb.scienze.univr.it/ncrnadb/. It is equipped with three interfaces: web based, command-line, and a Cytoscape app called ncINetView. By accessing only one resource, users can search for ncRNAs and their interactions, build a network annotated with all known ncRNAs and associated diseases, and use all visual and mining features available in Cytoscape. |