| URL: | http://statdb.bic.nus.edu.sg |
| Full name: | Signal Transducers and Activators of Transcription |
| Description: | STATdb is a specialized database for STAT proteins. The database provides a resource for systematic analyses of STAT proteins. STATdb consists of various features, see alongside, which comprises of data visualization, analysis and community contribution. STATdb is integrated with sequence analysis and similarity search tools such as BLAST, on the fly multiple sequence alignment and also includes prediction of unknown or novel STAT proteins. The data included has been obtained from the public databases and annotated with experimental status, domain sequences, domain architecture and STATdb classification which integrates STAT domain architecture, species lineage and function. |
| Year founded: | 2014 |
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| Accessibility: |
Accessible
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| Country/Region: | Singapore |
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| University/Institution: | National University of Singapore |
| Address: | Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, |
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| Country/Region: | Singapore |
| Contact name (PI/Team): | Tin Wee Tan |
| Contact email (PI/Helpdesk): | tinwee@bic.nus.edu.sg |
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STATdb: a specialised resource for the STATome. [PMID: 25157689]
Signal transducers and activators of transcription (STAT) proteins are key signalling molecules in metazoans, implicated in various cellular processes. Increased research in the field has resulted in the accumulation of STAT sequence and structure data, which are scattered across various public databases, missing extensive functional annotations, and prone to effort redundancy because of the dearth of community sharing. Therefore, there is a need to integrate the existing sequence, structure and functional data into a central repository, one that is enriched with annotations and provides a platform for community contributions. Herein, we present STATdb (publicly available at http://statdb.bic.nus.edu.sg/), the first integrated resource for STAT sequences comprising 1540 records representing the known STATome, enriched with existing structural and functional information from various databases and literature and including manual annotations. STATdb provides advanced features for data visualization, analysis and prediction, and community contributions. A key feature is a meta-predictor to characterise STAT sequences based on a novel classification that integrates STAT domain architecture, lineage and function. A curation policy workflow has been devised for regulated and structured community contributions, with an update policy for the seamless integration of new data and annotations. |