| URL: | http://bnet.egr.vcu.edu/miRegulome |
| Full name: | miRNA regulomics and analysis |
| Description: | miRegulome is an integrated online repository that provides entire regulatory modules of a miRNA, based on manually curated validated published data. Each module is hyperlinked to appropriate external database such as CTD, mir2Disease, miRNApath, KEGG, Entrez, and PubMed etc. to give the best possible picture of a miRNA regulome. The modules of a miRNA regulome consist of upstream regulators (transcription factors and various chemicals), downstream targets, pathways, functions, and disease associations etc. The relationships between modules and miRNA and experimental details have also been provided. |
| Year founded: | 2015 |
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| Accessibility: |
Accessible
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| Country/Region: | India |
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| University/Institution: | Institute of Integrative Omics and Applied Biotechnology |
| Address: | Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India |
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| Country/Region: | India |
| Contact name (PI/Team): | Debmalya Barh |
| Contact email (PI/Helpdesk): | dr.barh@gmail.com |
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miRegulome: a knowledge-base of miRNA regulomics and analysis. [PMID: 26243198]
miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community. |