DRAMP


34390348	DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides. [PMID: 34390348] Guobang Shi, Xinyue Kang, Fanyi Dong, Yanchao Liu, Ning Zhu, Yuxuan Hu, Hanmei Xu, Xingzhen Lao, Heng Zheng Abstract Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/. Nucleic Acids Res. 2021:() \| 94 Citations (from Europe PMC, 2025-03-15)
31409791	DRAMP 2.0, an updated data repository of antimicrobial peptides. [PMID: 31409791] Xinyue Kang, Fanyi Dong, Cheng Shi, Shicai Liu, Jian Sun, Jiaxin Chen, Haiqi Li, Hanmei Xu, Xingzhen Lao, Heng Zheng Abstract Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/ ) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs. Sci Data. 2019:6(1) \| 140 Citations (from Europe PMC, 2025-03-15)

DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides. [PMID: 34390348]

Guobang Shi, Xinyue Kang, Fanyi Dong, Yanchao Liu, Ning Zhu, Yuxuan Hu, Hanmei Xu, Xingzhen Lao, Heng Zheng

Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/.

Nucleic Acids Res. 2021:() | 94 Citations (from Europe PMC, 2025-03-15)

DRAMP 2.0, an updated data repository of antimicrobial peptides. [PMID: 31409791]

Xinyue Kang, Fanyi Dong, Cheng Shi, Shicai Liu, Jian Sun, Jiaxin Chen, Haiqi Li, Hanmei Xu, Xingzhen Lao, Heng Zheng

Abstract

Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/ ) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs.

Sci Data. 2019:6(1) | 140 Citations (from Europe PMC, 2025-03-15)

URL:	http://dramp.cpu-bioinfor.org
Full name:	data repository of antimicrobial peptides.
Description:	DRAMP(Data repository of antimicrobial peptides) is an open-access and manually curated database harboring diverse annotations of AMPs including sequences, structures, activities, physicochemical, patent, clinical and reference information. The clinical dataset also includes information on the clinical trial phase, therapeutic applications, company and preclinical or clinical AMP literature sources.
Year founded:	2019
Last update:
Version:
Accessibility:	Accessible
Country/Region:	China

Data type:	Protein
Data object:	Bacteria
Database category:	Interaction Modification Structure
Major species:	NA
Keywords:	antimicrobial peptides

University/Institution:	China Pharmaceutical University
Address:	Zheng Heng, Ph.D. Sub-platform of Biomedicine Technology Transfer of Technology Transfer Platform, Nanjing University National Demonstration Base for Innovation and Entrepreneurship; School of Life Science and Technology, China Pharmaceutical University; Institute of Medical and Pharmaceutical Biotechnology, Jiangsu Industrial Technology Research Institute zhengh18@hotmail.com
City:	Nanjing
Province/State:	Jiangsu
Country/Region:	China
Contact name (PI/Team):	Zheng Heng
Contact email (PI/Helpdesk):	zhengh18@hotmail.com

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Database Commons a catalog of worldwide biological databases