uORFlight


32168374	uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes. [PMID: 32168374] Niu R, Zhou Y, Zhang Y, Mou R, Tang Z, Wang Z, Zhou G, Guo S, Yuan M, Xu G. Abstract Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotypic changes. The paucity of such evidence encouraged us to generate this database-uORFlight (http://uorflight.whu.edu.cn). It facilitates the exploration of uORF variation among different splicing models of Arabidopsis and rice genes. Most importantly, users can evaluate uORF frequency among different accessions at the population scale and find out the causal single nucleotide polymorphism (SNP) or insertion/deletion (INDEL), which can be associated with phenotypic variation through database mining or simple experiments. Such information will help to make hypothesis of uORF function in plant development or adaption to changing environments on the basis of the cognate mORF function. This database also curates plant uORF relevant literature into distinct groups. To be broadly interesting, our database expands uORF annotation into more species of fungus (Botrytis cinerea and Saccharomyces cerevisiae), plant (Brassica napus, Glycine max, Gossypium raimondii, Medicago truncatula, Solanum lycopersicum, Solanum tuberosum, Triticum aestivum and Zea mays), metazoan (Caenorhabditis elegans and Drosophila melanogaster) and vertebrate (Homo sapiens, Mus musculus and Danio rerio). Therefore, uORFlight will light up the runway toward how uORF genetic variation determines phenotypic diversity and advance our understanding of translational control mechanisms in eukaryotes. Database (Oxford). 2020:2020() \| 21 Citations (from Europe PMC, 2025-03-22)

uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes. [PMID: 32168374]

Niu R, Zhou Y, Zhang Y, Mou R, Tang Z, Wang Z, Zhou G, Guo S, Yuan M, Xu G.

Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotypic changes. The paucity of such evidence encouraged us to generate this database-uORFlight (http://uorflight.whu.edu.cn). It facilitates the exploration of uORF variation among different splicing models of Arabidopsis and rice genes. Most importantly, users can evaluate uORF frequency among different accessions at the population scale and find out the causal single nucleotide polymorphism (SNP) or insertion/deletion (INDEL), which can be associated with phenotypic variation through database mining or simple experiments. Such information will help to make hypothesis of uORF function in plant development or adaption to changing environments on the basis of the cognate mORF function. This database also curates plant uORF relevant literature into distinct groups. To be broadly interesting, our database expands uORF annotation into more species of fungus (Botrytis cinerea and Saccharomyces cerevisiae), plant (Brassica napus, Glycine max, Gossypium raimondii, Medicago truncatula, Solanum lycopersicum, Solanum tuberosum, Triticum aestivum and Zea mays), metazoan (Caenorhabditis elegans and Drosophila melanogaster) and vertebrate (Homo sapiens, Mus musculus and Danio rerio). Therefore, uORFlight will light up the runway toward how uORF genetic variation determines phenotypic diversity and advance our understanding of translational control mechanisms in eukaryotes.

Database (Oxford). 2020:2020() | 21 Citations (from Europe PMC, 2025-03-22)

URL:	http://uorflight.whu.edu.cn
Full name:	Upstream open reading frames light
Description:	Database expands uORF annotation into more species of fungi (Botrytis cinerea, Saccharomyces cerevisiae), plant (Brassica napus, Glycine max, Gossypium raimondii, Medicago truncatula, Solanum lycopersicum, Solanum tuberosum,Triticum aestivum and Zea mays), metazoan (Caenorhabditis elegans and Drosophila melanogaster) and vertebrate (Homo sapiens, Mus musculus and Danio rerio). Therefore, uORFlight will light up the runway toward how uORF genetic variation determines phenotypic diversity and advance our understanding of translational control mechanisms in eukaryotes.
Year founded:	2020
Last update:	2020
Version:	1
Accessibility:	Accessible
Country/Region:	China

Data type:	DNA RNA
Data object:	Plant
Database category:	Literature Structure
Major species:	Botrytis cinerea Brassica napus Glycine max Gossypium raimondii Medicago truncatula Solanum lycopersicum Solanum tuberosum Triticum aestivum Zea mays Caenorhabditis elegans Drosophila melanogaster Homo sapiens Mus musculus Danio rerio
Keywords:	upstream open reading frame

University/Institution:	Wuhan University
Address:	State Key Laboratory of Hybrid Rice, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, China
City:	Wuhan
Province/State:	Hubei
Country/Region:	China
Contact name (PI/Team):	Guoyong Xu
Contact email (PI/Helpdesk):	guoyong.xu@whu.edu.cn

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