FuncPEP


32977531	FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs. [PMID: 32977531] Dragomir MP, Manyam GC, Ott LF, Berland L, Knutsen E, Ivan C, Lipovich L, Broom BM, Calin GA. Abstract Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading frames (smORFs), many initiating with the traditional AUG start codon but terminating with atypical stop codons, suggesting a different biogenesis. The ncRNA-encoded peptides (ncPEPs) are gradually becoming appreciated as a new class of functional molecules that contribute to diverse cellular processes, and are deregulated in different diseases contributing to pathogenesis. As multiple publications have identified unique ncPEPs, we appreciated the need for assembling a new web resource that could gather information about these functional ncPEPs. We developed FuncPEP, a new database of functional ncRNA encoded peptides, containing all experimentally validated and functionally characterized ncPEPs. Currently, FuncPEP includes a comprehensive annotation of 112 functional ncPEPs and specific details regarding the ncRNA transcripts that encode these peptides. We believe that FuncPEP will serve as a platform for further deciphering the biologic significance and medical use of ncPEPs. Noncoding RNA. 2020:6(4) \| 40 Citations (from Europe PMC, 2025-03-15)

FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs. [PMID: 32977531]

Dragomir MP, Manyam GC, Ott LF, Berland L, Knutsen E, Ivan C, Lipovich L, Broom BM, Calin GA.

Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading frames (smORFs), many initiating with the traditional AUG start codon but terminating with atypical stop codons, suggesting a different biogenesis. The ncRNA-encoded peptides (ncPEPs) are gradually becoming appreciated as a new class of functional molecules that contribute to diverse cellular processes, and are deregulated in different diseases contributing to pathogenesis. As multiple publications have identified unique ncPEPs, we appreciated the need for assembling a new web resource that could gather information about these functional ncPEPs. We developed FuncPEP, a new database of functional ncRNA encoded peptides, containing all experimentally validated and functionally characterized ncPEPs. Currently, FuncPEP includes a comprehensive annotation of 112 functional ncPEPs and specific details regarding the ncRNA transcripts that encode these peptides. We believe that FuncPEP will serve as a platform for further deciphering the biologic significance and medical use of ncPEPs.

Noncoding RNA. 2020:6(4) | 40 Citations (from Europe PMC, 2025-03-15)

URL:	https://bioinformatics.mdanderson.org/Supplements/FuncPEP/
Full name:	functional ncRNA encoded peptides
Description:	FuncPEP is a new database of functional ncRNA encoded peptides (ncPEPs), containing all experimentally validated and functionally characterized ncPEPs. FuncPEP provides an interface of a dynamic table to browse the non-coding peptides. Currently, FuncPEP includes a comprehensive annotation of 112 functional ncPEPs and specific details regarding the ncRNA transcripts that encode these peptides.
Year founded:	2020
Last update:
Version:	v1.0
Accessibility:	Accessible
Country/Region:	United States

Data type:	Protein RNA
Data object:	Animal Bacteria Plant Virus
Database category:	Expression Gene genome and annotation
Major species:	Danio rerio Rattus norvegicus Physcomitrella patens Mus musculus Medicago truncatula Human gammaherpesvirus 8 Homo sapiens Escherichia coli Drosophila melanogaster
Keywords:	ncRNA-encoded peptides ncRNA

University/Institution:	The University of Texas MD Anderson Cancer Center
Address:	Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
City:	Houston
Province/State:
Country/Region:	United States
Contact name (PI/Team):	George A. Calin
Contact email (PI/Helpdesk):	gcalin@mdanderson.org

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Database Commons a catalog of worldwide biological databases