| URL: | https://www.gpsadb.com |
| Full name: | Genetic Perturbation Similarity Analysis |
| Description: | GPSAdb is a powerful platform that aims to assist life science researchers to easily access and analyze public perturbed data and explore differential gene expression data in depth. The current version of GPSAdb collected 3048 RNA-seq datasets associated with 1458 genes, which were knocked out/down by siRNA, shRNA, CRISPR/Cas9, or CRISPRi. |
| Year founded: | 2021 |
| Last update: | 2022-08-25 |
| Version: | v1.1.7 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Children's Hospital of Chongqing Medical University |
| Address: | Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. |
| City: | Chongqing |
| Province/State: | |
| Country/Region: | China |
| Contact name (PI/Team): | Shipeng Guo |
| Contact email (PI/Helpdesk): | guoshipeng2008@126.com |
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GPSAdb: a comprehensive web resource for interactive exploration of genetic perturbation RNA-seq datasets. [PMID: 36416261]
Gene knock-out/down methods are commonly used to explore the functions of genes of interest, but a database that systematically collects perturbed data is not available currently. Manual curation of all the available human cell line perturbed RNA-seq datasets enabled us to develop a comprehensive human perturbation database (GPSAdb, https://www.gpsadb.com/). The current version of GPSAdb collected 3048 RNA-seq datasets associated with 1458 genes, which were knocked out/down by siRNA, shRNA, CRISPR/Cas9, or CRISPRi. The database provides full exploration of these datasets and generated 6096 new perturbed gene sets (up and down separately). GPSAdb integrated the gene sets and developed an online tool, genetic perturbation similarity analysis (GPSA), to identify candidate causal perturbations from differential gene expression data. In summary, GPSAdb is a powerful platform that aims to assist life science researchers to easily access and analyze public perturbed data and explore differential gene expression data in depth. |