| URL: | http://www.medsysbio.org/FDRdb |
| Full name: | Fibrotic Disease-associated RNAome database |
| Description: | FDRdb is an open and up-to-data online manually curated depository of RNAs alterations and high-throughput datasets about fibrotic diseases across various species. The current version of FDRdb documents 1950 associations between 912 RNAs and 92 fibrotic diseases in 8 species, manually collected from 1127 published literature, and collects information on 765 datasets of fibrotic diseases, including 624 RNA expression profiles, 32 methylation profiles and 108 sequencing datasets. |
| Year founded: | 2022 |
| Last update: | |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Harbin Medical University |
| Address: | Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China. |
| City: | Harbin |
| Province/State: | Heilongjiang |
| Country/Region: | China |
| Contact name (PI/Team): | Haihai Liang |
| Contact email (PI/Helpdesk): | lianghaihai@ems.hrbmu.edu.cn |
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FDRdb: a manually curated database of fibrotic disease-associated RNAome and high-throughput datasets. [PMID: 36367312]
Fibrosis is a common and serious disease that exists as a complicated impairment in many organs and triggers a complex cascade of responses. The deregulation of Ribonucleic Acids (RNAs) plays important roles in a variety of organ fibrosis cases. However, for fibrotic diseases, there is still a lack of an integrated platform with up-to-date information on RNA deregulation and high-throughput data. The Fibrotic Disease-associated RNAome database (FDRdb) (http://www.medsysbio.org/FDRdb) is a manually curated database of fibrotic disease-associated RNAome information and high-throughput datasets. This initial release (i) contains 1947 associations between 912 RNAs and 92 fibrotic diseases in eight species; (ii) collects information on 764 datasets of fibrotic diseases; (iii) provides a user-friendly web interface that allows users to browse, search and download the RNAome information on fibrotic diseases and high-throughput datasets and (iv) provides tools to analyze the expression profiles of fibrotic diseases, including differential expression analysis and pathway enrichment. The FDRdb is a valuable resource for researchers to explore the mechanisms of RNA dysregulation in organ fibrosis. Database URL: http://www.medsysbio.org/FDRdb. |