MLOsMetaDB


38063081	MLOsMetaDB, a meta-database to centralize the information on liquid-liquid phase separation proteins and membraneless organelles. [PMID: 38063081] Fernando Orti, María Laura Fernández, Cristina Marino-Buslje Abstract Over the past few years, there has been a focus on proteins that create separate liquid phases in the intracellular liquid environment, known as membraneless organelles (MLOs). These organelles allow for the spatiotemporal associations of macromolecules that dynamically exchange within the cellular milieu. They provide a form of compartmentalization crucial for organizing key functions in many cells. Metabolic processes and signaling pathways in both the cytoplasm and nucleus are among the functions performed by MLOs, which are facilitated by diverse combinations of proteins and nucleic acids. However, disruptions in these liquid-liquid phase separation processes (LLPS) may lead to several diseases, such as neurodegenerative disorders and cancer, among others. To foster the study of this process and MLO function, we present MLOsMetaDB (http://mlos.leloir.org.ar), a comprehensive resource of information on MLO- and LLPS-related proteins. Our database integrates and centralizes available information for every protein involved in MLOs, which is otherwise disseminated across a plethora of different databases. Our manuscript outlines the development and features of MLOsMetaDB, which provides an interactive and user-friendly environment with modern biological visualizations and easy and quick access to proteins based on LLPS role, MLO location, and organisms. In addition, it offers an advanced search for making complex queries to generate customized information. Furthermore, MLOsMetaDB provides evolutionary information by collecting the orthologs of every protein in the same database. Overall, MLOsMetaDB is a valuable resource as a starting point for researchers studying the many processes driven by LLPS proteins and membraneless organelles. Protein Sci. 2024:33(1) \| 3 Citations (from Europe PMC, 2025-03-29)

MLOsMetaDB, a meta-database to centralize the information on liquid-liquid phase separation proteins and membraneless organelles. [PMID: 38063081]

Fernando Orti, María Laura Fernández, Cristina Marino-Buslje

Abstract

Over the past few years, there has been a focus on proteins that create separate liquid phases in the intracellular liquid environment, known as membraneless organelles (MLOs). These organelles allow for the spatiotemporal associations of macromolecules that dynamically exchange within the cellular milieu. They provide a form of compartmentalization crucial for organizing key functions in many cells. Metabolic processes and signaling pathways in both the cytoplasm and nucleus are among the functions performed by MLOs, which are facilitated by diverse combinations of proteins and nucleic acids. However, disruptions in these liquid-liquid phase separation processes (LLPS) may lead to several diseases, such as neurodegenerative disorders and cancer, among others. To foster the study of this process and MLO function, we present MLOsMetaDB (http://mlos.leloir.org.ar), a comprehensive resource of information on MLO- and LLPS-related proteins. Our database integrates and centralizes available information for every protein involved in MLOs, which is otherwise disseminated across a plethora of different databases. Our manuscript outlines the development and features of MLOsMetaDB, which provides an interactive and user-friendly environment with modern biological visualizations and easy and quick access to proteins based on LLPS role, MLO location, and organisms. In addition, it offers an advanced search for making complex queries to generate customized information. Furthermore, MLOsMetaDB provides evolutionary information by collecting the orthologs of every protein in the same database. Overall, MLOsMetaDB is a valuable resource as a starting point for researchers studying the many processes driven by LLPS proteins and membraneless organelles.

Protein Sci. 2024:33(1) | 3 Citations (from Europe PMC, 2025-03-29)

URL:	http://mlos.leloir.org.ar
Full name:	membraneless organelles meta database
Description:	MLOsMetaDB is a comprehensive resource of information on MLO- and LLPS-related proteins. Our database integrates and centralizes available information for every protein involved in MLOs, which is otherwise disseminated across a plethora of different databases.
Year founded:	2023
Last update:	2023
Version:
Accessibility:	Accessible
Country/Region:	Argentina

Data type:	Protein
Data object:	Animal Plant
Database category:	Gene genome and annotation Interaction Structure
Major species:	Homo sapiens Mus musculus Arabidopsis thaliana Saccharomyces cerevisiae Caenorhabditis elegans Bos taurus Drosophila melanogaster Rattus norvegicus Xenopus laevis
Keywords:	LLPS-associated proteins biocondensates membraneless organelles (MLOs) molecular condensates phase separation

University/Institution:	Leloir Institute
Address:
City:
Province/State:
Country/Region:	Argentina
Contact name (PI/Team):	Cristina Marino-Buslje
Contact email (PI/Helpdesk):	cmb@leloir.org.ar

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Database Commons a catalog of worldwide biological databases