MFPPDB


37908832	MFPPDB: a comprehensive multi-functional plant peptide database. [PMID: 37908832] Yaozu Yang, Hongwei Wu, Yu Gao, Wei Tong, Ke Li Abstract Plants produce a wide range of bioactive peptides as part of their innate defense mechanisms. With the explosive growth of plant-derived peptides, verifying the therapeutic function using traditional experimental methods are resources and time consuming. Therefore, it is necessary to predict the therapeutic function of plant-derived peptides more effectively and accurately with reduced waste of resources and thus expedite the development of plant peptides. We herein developed a repository of plant peptides predicted to have multiple therapeutic functions, named as MFPPDB (multi-functional plant peptide database). MFPPDB including 1,482,409 single or multiple functional plant origin therapeutic peptides derived from 121 fundamental plant species. The functional categories of these therapeutic peptides include 41 different features such as anti-bacterial, anti-fungal, anti-HIV, anti-viral, and anti-cancer. The detailed physicochemical information of these peptides was presented in functional search and physicochemical property search module, which can help users easily access the peptide information by the plant peptide species, ID, and functions, or by their peptide ID, isoelectric point, peptide sequence, and molecular weight through web-friendly interface. We further matched the predicted peptides to nine state-of-the-art curated functional peptide databases and found that at least 293,408 of the peptides possess functional potentials. Overall, MFPPDB integrated a massive number of plant peptides have single or multiple therapeutic functions, which will facilitate the comprehensive research in plant peptidomics. MFPPDB can be freely accessed through http://124.223.195.214:9188/mfppdb/index. Front Plant Sci. 2023:14() \| 3 Citations (from Europe PMC, 2025-03-22)

MFPPDB: a comprehensive multi-functional plant peptide database. [PMID: 37908832]

Yaozu Yang, Hongwei Wu, Yu Gao, Wei Tong, Ke Li

Plants produce a wide range of bioactive peptides as part of their innate defense mechanisms. With the explosive growth of plant-derived peptides, verifying the therapeutic function using traditional experimental methods are resources and time consuming. Therefore, it is necessary to predict the therapeutic function of plant-derived peptides more effectively and accurately with reduced waste of resources and thus expedite the development of plant peptides. We herein developed a repository of plant peptides predicted to have multiple therapeutic functions, named as MFPPDB (multi-functional plant peptide database). MFPPDB including 1,482,409 single or multiple functional plant origin therapeutic peptides derived from 121 fundamental plant species. The functional categories of these therapeutic peptides include 41 different features such as anti-bacterial, anti-fungal, anti-HIV, anti-viral, and anti-cancer. The detailed physicochemical information of these peptides was presented in functional search and physicochemical property search module, which can help users easily access the peptide information by the plant peptide species, ID, and functions, or by their peptide ID, isoelectric point, peptide sequence, and molecular weight through web-friendly interface. We further matched the predicted peptides to nine state-of-the-art curated functional peptide databases and found that at least 293,408 of the peptides possess functional potentials. Overall, MFPPDB integrated a massive number of plant peptides have single or multiple therapeutic functions, which will facilitate the comprehensive research in plant peptidomics. MFPPDB can be freely accessed through http://124.223.195.214:9188/mfppdb/index.

Front Plant Sci. 2023:14() | 3 Citations (from Europe PMC, 2025-03-22)

URL:	http://124.223.195.214:9188/mfppdb/index
Full name:	Multi-functional plant peptide database
Description:	MFPPDB is a comprehensive database that catalogs plant-derived peptides with predicted therapeutic functions, covering a wide range of bioactivities such as anti-bacterial, anti-fungal, anti-viral, and anti-cancer. It provides detailed physicochemical information and supports functional searches, facilitating research in plant peptidomics and the development of plant-based therapeutic agents.
Year founded:	2023
Last update:
Version:	v1.0
Accessibility:	Unaccessible
Country/Region:	China

Data type:	Protein
Data object:	Plant
Database category:	Gene genome and annotation Health and medicine
Major species:	Hordeum vulgare Thinopyrum intermedium Zea mays Camellia sinensis Citrus clementina Carica papaya Brachypodium mexicanum Musa acuminata Oropetium thomaeum Cucumis sativus Spinacia oleracea
Keywords:	multi-functional peptidome plant therapeutic peptide

University/Institution:	Anhui Agricultural University
Address:	Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China.
City:	Hefei
Province/State:	Anhui
Country/Region:	China
Contact name (PI/Team):	Ke Li
Contact email (PI/Helpdesk):	bsblike@163.com

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Database Commons a catalog of worldwide biological databases