Disease - EDK - BIG Data Center

Virus	Disease	Enzyme	Host	PMID
Human T-cell leukemia virus type 2	Leukemia	ADAR1	Human	22993189
Human T-lymphotropic virus type 1	Leukemia	APOBEC3G; APOBEC3A; APOBEC3B	Human	22457529
Simian T-cell leukemia virus type 3	Leukemia	ADAR1	Simian	22993189

Enzyme	Full Name	Location	Ensembl	Targets	Related Diseases	Aliases
ADAR1	Adenosine deaminase, RNA specific	Chr1:154582057..154631560	ENSG00000160710	AZIN1 FLNB NEIL1 GLI1 hsa-Let-7a-1 hsa-miR-222 hsa-miR-381	Aicardi-Goutires syndrome Breast Cancer Dyschromatosis Symmetrica Hereditaria Human immunodeficiency virus infectious disease Measles Vesicular stomatitis Anxiety disorder Chronic Myeloid Leukemia Lung Cancer Sepsis Melanoma Leukemia Esophageal Squamous Cell Carcinoma Epithelial Ovarian Cancers Ovarian Cancer Sepsis	AGS6 DRADA DSH DSRAD G1P1 IFI-4 IFI4 K88DSRBP P136
APOBEC3	Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3	Chr22:38957522..39087743	ENSG00000128383 ENSG00000179750 ENSG00000244509 ENSG00000243811 ENSG00000128394 ENSG00000239713	virus HBV core protein, enhancer II, promoter	Acute Myeloid Leukemia Hepatocellular Carcinoma Chronic Hepatitis Renal Cell Carcinoma	APOBEC3A APOBEC3B APOBEC3C APOBEC3DE APOBEC3F APOBEC3G APOBEC3H