EDK
Editome Disease Knowledgebase
AZIN1
| Gene symbol | AZIN1 |
|---|---|
| Aliases | - |
| Protein Name | Antizyme inhibitor 1 protein |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. The wild-type AZIN1 could promote the tumorigenicity, the edited AZIN1 promotes cell proliferation and possibly the Hepatocellular Carcinoma onset and progression. |
| Species | Human |
| Editing Sites | 2 |
| Disease | Hepatocellular Carcinoma; Esophageal Squamous Cell Carcinoma; |
| Description | The edited AZIN1 promotes cell proliferation and possibly the Hepatocellular Carcinoma onset and progression. The wild-type AZIN1 could promote the tumorigenicity, the edited AZIN1 conferred gain-of-function phenotypes that were manifested by more aggressive behaviors during Esophageal Squamous Cell Carcinoma progression. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | O14977(Uniport); NM_015878 (NM id); 51582 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 367 | 1872 | AGC->GGC | S->G | Nonsynonymous substitution | Present | Liver | Neutralize the antizyme-mediated degradation of ODC and CCND1 | Edited AZIN1 promotes cell proliferation and possibly the HCC onset and progression. | Promote tumor cell proliferation | ||
|
A-to-I | CDS | 367 | 1872 | AGC->GGC | S->G | Nonsynonymous substitution | Present | Esophageal | Neutralize the antizyme-mediated degradation of ODC and CCND1 | The edited AZIN1 conferred gain-of-function phenotypes that are manifested by more aggressive behaviors during ESCC progression. | Promote aggressive behaviors in tumor progression | ||
|
A-to-I | NA | NA | NA | NA | NA | mRNA expression change | Increased | cancer-associated fibroblasts | NA | mRNA expression change | Enhanced the invasive potential of fibroblasts | ||
|
A-to-I | NA | NA | NA | NA | NA | mRNA expression change | Increased | gastric tissues | NA | mRNA expression change | Hyperediting status of AZIN1 RNA was an independent risk factor for lymph node metastasis |