Gene symbol | HTR2C |
---|---|
Aliases | - |
Protein Name | 5-hydroxytryptamine receptor 2C |
Function | The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. Dampening of serotonergic neurotransmission via RNA editing of 5-HT2C receptors. |
Species | Human |
Editing Sites | 6 |
Disease | Depression; |
Description | Dampening of serotonergic neurotransmission via RNA editing of 5-HT2C receptors. The research has identified that cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. |
RADR | RADAR |
REDIportal | REDI portal |
External links | P28335(Uniport); NM_001256760 (NM id); 3358 (NCBI gene id); GeneCard; GTEx |
Sequence |
Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 156 | 1287 | AUA->GUA | I->V | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease | ||
|
A-to-I | CDS | 156 | 1289 | AUA->AUG | I->M | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease | ||
|
A-to-I | CDS | 158 | 1292 | AAU->AGU | N->S | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease | ||
|
A-to-I | CDS | 158 | 1291 | AAU->GAU | N->D | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease | ||
|
A-to-I | CDS | 158 | 1292 | AAU->GGU | N->G | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease | ||
|
A-to-I | CDS | 160 | 1300 | AUU->GUU | I->V | Nonsynonymous substitution | Present | Brain | Dampen the quantity of serotonergic neurotransmission | Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. | Induce disease |