Disease - EDK - BIG Data Center

Disease name	Melanoma
Classfication	Cancer
Related Enzyme(s)	ADAR1
EFO	EFO:0000756
DOID	1909
OMIM	OMIM:155600
NCI	NCI:C3224
Definition	A cell type cancer that has material basis in abnormally proliferating cells derived from melanocytes which are found in skin, the bowel and the eye.

Gene symbol	Disease	Enzyme	Editing Sites	Editing Type	miRBase	PMID	Description
hsa-miR-455-5p	Melanoma	ADAR1	2	A-to-I	MI0003513	25686251	miR-455-5p has two A-to-I RNA editing sites, one at mature position 2 and one at mature position 17 The biological function of edited miR-455-5p is different from the unedited form as it recognizes a different set of genes. miR-455-5p promotes melanoma metastasis via inhibition of the tumor suppressor gene CPEB1. Moreover, miR-455 enhances melanoma growth and metastasis in vivo while the edited form inhibits these features.
hsa-miR-378a-3p	Melanoma	ADAR1	1	A-to-I	MIMAT0000732	29386624	The edited form of miR-378a-3p preferentially binds to the 3'UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype.
has-mir-200b	Melanoma	ADAR1	1	A-to-G			According to TCGA data, the tumor suppressor miR-200b is overedited in thyroid tumors, and its levels of editing correlate with a worse progression-free survival and disease stage
has-mir-149	Melanoma	ADAR1	1	A-to-G			ADAR1p150 can promote the biosynthesis and function of miRNA-149* in melanoma cells which makes it be considered as both a bio-marker and a therapeutic target for treatment of melanoma.

Enzyme	Full Name	Location	Ensembl	Targets	Related Diseases	Aliases
ADAR1	Adenosine deaminase, RNA specific	Chr1:154582057..154631560	ENSG00000160710	AZIN1 FLNB NEIL1 GLI1 hsa-Let-7a-1 hsa-miR-222 hsa-miR-381	Aicardi-Goutires syndrome Breast Cancer Dyschromatosis Symmetrica Hereditaria Human immunodeficiency virus infectious disease Measles Vesicular stomatitis Anxiety disorder Chronic Myeloid Leukemia Lung Cancer Sepsis Melanoma Leukemia Esophageal Squamous Cell Carcinoma Epithelial Ovarian Cancers Ovarian Cancer Sepsis	AGS6 DRADA DSH DSRAD G1P1 IFI-4 IFI4 K88DSRBP P136