EDK Editome Disease Knowledgebase

  1. Home
  2. Enzyme
  3. ADAR3

Basic Information

Enzyme ADAR3
Full Name Adenosine deaminase, RNA specific B2
Location Chr10:1177313..1737476
Ensembl ENSG00000185736
Aliases ADARB2;DRABA2;RED2

Disease Related Information

Disease Species Regulator Expression/Aberrance Target Target Function Regulation Editing-Level Relationship Correlation Editing Effect Phenotype Editing-Dependent PMID
Glioblastoma Human NA Increase GRIA2 Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Deficiency of Glur2 editing may lead to nervous disease. increased expression of ADAR3 decreases Q/R site of GRIA2 editing in nearly all the tumors compared to adjacent tissue. Decreased Correlated Positive NA Affect Glioblastoma Yes
Astrocytomas Human NA Increase GRIA2 Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Deficiency of Glur2 editing may lead to nervous disease. Overexpression of ADAR3 in astrocyte and astrocytoma cell lines inhibits RNA editing at the Q/R site of GRIA2. Decreased Correlated Positive ADAR3 inhibits editing of the glutamate receptor in astrocytes, suggesting that ADAR3 may regulate neuronal RNA editing and contribute to ALS physiology. Affect Astrocytomas Yes