EDK
Editome Disease Knowledgebase
Basic Information
| Enzyme | APOBEC1 |
|---|---|
| Full Name | Apolipoprotein B mRNA editing enzyme catalytic subunit 1 |
| Location | Chr12:8602166..8612970 |
| Ensembl | ENSG00000111701 |
| Aliases | BEDP;HEPR;CDAR1;APOBEC-1 |
Disease Related Information
| Disease | Species | Regulator | Expression/Aberrance | Target | Target Function | Regulation | Editing-Level | Relationship | Correlation | Editing Effect | Phenotype | Editing-Dependent | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular Carcinoma | Human | NA | Decrease | apoB mRNA | NA | The low-level expression results in sufficient APOBEC-1 to edit essentially all apoB mRNA at the normal editing site, while intermediate (I-20) or high (I-28) levels expression results in hyperediting at multiple sites. | Decreased | Correlated | Negative | Hepatic expression of apolipoprotein (apo) B mRNA lowers plasma LDL levels. | Inhibit liver dysplasia and hepatocellular carcinoma | Yes |