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Basic Information

Enzyme APOBEC3
Full Name Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3
Location Chr22:38957522..39087743
Ensembl ENSG00000128383;ENSG00000179750;ENSG00000244509;ENSG00000243811;ENSG00000128394;ENSG00000239713
Aliases APOBEC3A;APOBEC3B;APOBEC3C;APOBEC3DE;APOBEC3F;APOBEC3G;APOBEC3H

Disease Related Information

Disease Species Regulator Expression/Aberrance Target Target Function Regulation Editing-Level Relationship Correlation Editing Effect Phenotype Editing-Dependent PMID
Hepatocellular Carcinoma Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Hepatocellular Carcinoma Human IFN-α Increase virus HBV core protein, enhancer II, promoter NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Hepatocellular Carcinoma Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Hepatocellular Carcinoma Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Hepatocellular Carcinoma Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Chronic Hepatitis Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Chronic Hepatitis Human IFN-α Increase virus HBV core protein, enhancer II, promoter NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Chronic Hepatitis Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Chronic Hepatitis Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Chronic Hepatitis Human IFN-α Increase virus HBV core protein NA Increased A3 expression may contribute to the antiviral effects of IFN against HBV DNA. Increased Correlated Negative APOBECs edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. Promote virus escape from the immune resistance Yes
Renal Cell Carcinoma Human NA Increase NA NA APOBEC3B is overexpressed in multiple cancer types, and this overexpression correlates with the presence of the APOBEC3B mutation signature. Increased Correlated Positive High expression of APOBEC3B is associated with high-grade tumors and histologic necrosis. Promote risk of recurrence of the tumor Yes
Acute Myeloid Leukemia Human NA Increase NA NA A3A over-expression is associated with significant increase in significant increase in WT1 c.1303G>A mRNA editing. Increased Correlated Positive WT1 mutations affect the zinc finger (ZnF) domains in Wilms tumor and acute myeloid leukemia (AML). Induce mutation of acute myeloid leukemia Yes