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CDC14B

Gene symbol CDC14B
Aliases -
Protein Name Dual specificity protein phosphatase CDC14B
Function The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Species Human
Editing Sites 13
Disease Astrocytomas; Glioblastoma;
Description CDC14B editing and expression are progressively impaired in astrocytomas from grade I to IV, being very low in GBMs.
RADR RADAR
REDIportal REDI portal
External links O60729(Uniport); NM_003671 (NM id); 8555 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region NT Seq Position Editing Level Tissue Interaction Editing Effect Phenotype Disease name PMID
  • ADAR2
 A-to-I Downstream 87 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 103 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 111 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 112 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 115 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 127 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 136 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 175 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 177 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 206 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 228 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 228 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease
  • ADAR2
 A-to-I Downstream 228 Decreased Brain Reduce the quantity of Skp2 target protein NA Reduce RNA editing in disease