EDK
Editome Disease Knowledgebase
COG3
| Gene symbol | COG3 |
|---|---|
| Aliases | SEC34 |
| Protein Name | Conserved oligomeric Golgi complex subunit 3 |
| Function | |
| Species | Human |
| Editing Sites | 1 |
| Disease | Glioblastoma; |
| Description | Over-editing (>40%) at the COG3 I/V site plays a critical pro-tumoral role in GBM and correlates with a worse prognosis in GBM patients. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | chr13:46090371 | I->V | Recoding | chr13:46090371(19) | brain | NA | Over-editing (> 40%) at the COG3 I/V site with a worse prognosis in GBM patients |