mRNA - EDK - BIG Data Center

Gene symbol	CTSS
Aliases	-
Protein Name	Cathepsin S
Function	Cathepsin S is a member of the peptidase C1 family and is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation to the MHC class II. Deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.
Species	Human
Editing Sites	41
Disease	Atherosclerosis;
Description	RNA-editing in the CTSS 3'UTR will knockdown the CTSS mRNA expression, and RNA-editing of CTSS mRNA also regulate the RNA-binding protein HuR, deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo. And it will reduce the binding efficiency of HuR, which will lead to Decrease the stability of CTSS mRNA.
RADR	RADAR
REDIportal	REDI portal
External links	P25774(Uniport); NM_004079 (NM id); 1520 (NCBI gene id); GeneCard; GTEx
Sequence

Enzyme	Editing type	Region	NT Seq Position	Molecular Consequence	Editing Level	Tissue	Interaction	Editing Effect	Phenotype	Disease name	PMID
ADAR1	A-to-I	3'UTR	2125	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2126	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2143	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2146	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2280	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2288	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2293	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2296	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2298	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2303	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2336	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2361	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2919	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2929	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2953	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2967	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2967	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	2992	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3115	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3127	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3134	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3059	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3063	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3064	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3065	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3072	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3078	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3081	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3082	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3083	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3087	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3092	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3100	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3103	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3107	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3118	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3132	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3118	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3132	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3145	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325
ADAR1	A-to-I	3'UTR	3159	mRNA stability change	Present	Arteries	Reduce the binding efficiency of RNA-binding protein HuR	RNA-editing in the CTSS 3'UTR can knockdown the CTSS mRNA expression and deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo.	Reduce atherosclerosis and angiogenesis	Atherosclerosis;	27595325

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CTSS

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