EDK
Editome Disease Knowledgebase
DFFA
| Gene symbol | DFFA |
|---|---|
| Aliases | DFF1; ICAD; DFF-45 |
| Protein Name | DNA fragmentation factor subunit alpha |
| Function | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Breast Cancer; |
| Description | mRNA editing allowed this miRNA to directly target the apoptosis inducing gene DFFA in MCF-7, but not in MDA-MB-231 cells. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | NA | NA | miRNA binding sites gain | NA | NA | miR-140-3p | RNA-editng in DFFA changes the binding site of miRNA | d |