EDK
Editome Disease Knowledgebase
FAK
| Gene symbol | FAK |
|---|---|
| Aliases | |
| Protein Name | |
| Function | |
| Species | Human |
| Editing Sites | 1 |
| Disease | Lung Cancer; |
| Description | ADAR posttranscriptionally increased FAK protein abundance by binding to the FAK transcript and edit- ing a specific intronic site that resulted in the increased stabilization of FAK mRNA. Pharmacological inhibition of FAK blocked ADAR-induced invasiveness of LUAD cells, suggesting a potential therapeutic application for LUAD that has a high abundance of ADAR. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | intronic | chr8:141702274 | mRNA stability change | Presence | Human LUAD cells | mRNA stability change | FAK blocked ADAR-induced invasiveness of LUAD cells |