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GABRA-3

Gene symbol GABRA-3
Aliases -
Protein Name Gamma-aminobutyric acid receptor subunit alph
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Species Human
Editing Sites 1
Disease Anxiety disorder;
Description GABAA receptors respond to anxiolytic drugs such as benzodiazepines and are thus important drug targets. I/M editing could be important in determining the mechanistic features that are responsible for the diversity of GABAA receptors and the variability in sensitivity to drugs.
RADR RADAR
REDIportal REDI portal
External links P34903(Uniport); NM_000808 (NM id); 2556 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region NT Seq Position Codon Change Amino Acid Change Molecular Consequence Editing Level Tissue Editing Effect Phenotype Disease name PMID
  • ADAR1
  • ADAR2
 G-to-A CDS NA AUA->AUG I->M Nonsynonymous substitution Present Mouse brain I/M editing could be important in determining the mechanistic features that are responsible for the diversity of GABAA receptors and the variability in sensitivity to drugs. Affect the variability GABAA receptors in sensitivity to drugs.