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GRIA3

Gene symbol GRIA3
Aliases GLUR3
Protein Name Glutamate receptor 3
Function Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Species Rat
Editing Sites 1
Disease Spinal Cord Injury;
Description The molecular changes set in motion by SCI that affect the channel properties of AMPA receptors. SCI strongly reduced the level of AMPA receptor R/G editing, the reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death; however, prolonged suppression of GluR function in later stages may hinder synaptic plasticity.
RADR RADAR
REDIportal REDI portal
External links P42263(Uniport); NM_032990 (NM id); 29628 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region NT Seq Position Amino Acid Change Molecular Consequence Editing Level Tissue Editing Effect Phenotype Disease name PMID
  • ADAR2
 A-to-I CDS NA R->G Nonsynonymous substitution Decreased Spinal Cord The reduced editing at the R/G site of glutamate receptor subunits (GluRs) can limit the progression of cell death. Promote recovery