EDK
Editome Disease Knowledgebase
GRIA4
| Gene symbol | GRIA4 |
|---|---|
| Aliases | GLUR4 |
| Protein Name | Glutamate receptor 4 |
| Function | Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. |
| Species | Rat |
| Editing Sites | 1 |
| Disease | Spinal Cord Injury; |
| Description | The molecular changes set in motion by SCI that affect the channel properties of AMPA receptors. SCI strongly reduced the level of AMPA receptor R/G editing, the reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death; however, prolonged suppression of GluR function in later stages may hinder synaptic plasticity. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | P48058(Uniport); NM_017263 (NM id); 29628 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | NA | R->G | Nonsynonymous substitution | Decreased | Spinal Cord | The reduced editing at the R/G site of glutamate receptor subunits (GluRs) can limit the progression of cell death and prolonged suppression of GluR function in later stages may hinder synaptic plasticity. | Promote recovery |