EDK
Editome Disease Knowledgebase
HNRNPK
| Gene symbol | HNRNPK |
|---|---|
| Aliases | - |
| Protein Name | HnRNP K protein |
| Function | The heterogeneous nuclear ribonucleoprotein K (hnRNP K) protein is an RNA-binding protein involved in many processes that compose gene expression. K protein is upregulated in the malignant processes and has been shown to modulate the expression of genes involved in mitogenic responses and tumorigenesis. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Colorectal Cancer; |
| Description | G-to-A base substitution at position 274 of K protein mRNA that was found in colorectal tumors and surrounding mucosa, but not in individuals that had no colorectal tumor. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | P61978(Uniport); NM_002140 (NM id); 3190 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
G-to-A | Exonic | 274 | 1411 | GCU->ACU | A->T | Nonsynonymous substitution | Present | Mucosa | NA. | Affect disease processing |