EDK
Editome Disease Knowledgebase
SLC22A3
| Gene symbol | SLC22A3 |
|---|---|
| Aliases | - |
| Protein Name | Solute carrier family 22 member 3 |
| Function | SLC22A3 is a metastasis suppressor in ESCC, and deregulation of SLC22A3 facilitates cell invasion and filopodia formation by reducing its direct association with α-actinin-4 (ACTN4), leading to the increased actin-binding activity of ACTN4 in normal esophageal cells. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Esophageal Squamous Cell Carcinoma; |
| Description | A-to-I RNA editing may decrease the stability of SLC22A3 in familial cases, deregulated SLC22A3 Is an Early Risk Factor for Progression of Familial ESCC. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | O75751(Uniport); NM_021977 (NM id); 6581 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 71 | 261 | AAC->GAC | N->D | Nonsynonymous substitution | Present | Esophageal tissues | A-to-I RNA editing may decrease the stability of SLC22A3 in familial cases. | Promote the tumor progression and malignant development |