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XIAP

Gene symbol XIAP
Aliases API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
Protein Name E3 ubiquitin-protein ligase XIAP
Function This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their antiapoptotic function.
Species Human
Editing Sites 31
Disease Tumorigenesis;
Description Abrogation of ADAR1 expression or catalytic activity elicited a XIAP- dependent suppression of apoptotic response, whereas ectopic expression reversed this protective effect on cell death.
RADR RADAR
REDIportal REDI portal
External links (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region NT Seq Position Molecular Consequence Editing Level Tissue Interaction Editing Effect Phenotype Disease name PMID
  • ADAR1
 A-to-I 3'UTR chrX:123042943 protein products expression change chrX:123042943(19) HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123042979 protein products expression change chrX:123042979 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123043064 protein products expression change chrX:123043064 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044464 protein products expression change chrX:123044464 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044465 protein products expression change chrX:123044465 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044532 protein products expression change chrX:123044532 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044553 protein products expression change chrX:123044553 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044558 protein products expression change chrX:123044558 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123044559 protein products expression change chrX:123044559 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045113 protein products expression change chrX:123045113 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045132 protein products expression change chrX:123045132 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045138 protein products expression change chrX:123045138 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045142 protein products expression change chrX:123045142 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045170 protein products expression change chrX:123045170 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123045172 protein products expression change chrX:123045172 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123046591 protein products expression change chrX:123046591 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123046596 protein products expression change chrX:123046596 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123046599 protein products expression change chrX:123046599 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123046644 protein products expression change chrX:123046644 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123046720 protein products expression change chrX:123046720 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047048 protein products expression change chrX:123047048 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047126 protein products expression change chrX:123047126 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047165 protein products expression change chrX:123047165 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047169 protein products expression change chrX:123047169 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047170 protein products expression change chrX:123047170 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047173 protein products expression change chrX:123047173 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047181 protein products expression change chrX:123047181 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047240 protein products expression change chrX:123047240 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047241 protein products expression change chrX:123047241 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047270 protein products expression change chrX:123047270 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I 3'UTR chrX:123047285 protein products expression change chrX:123047285 HeLa, HepG2, WI38 and HEK293 cell lines STAU1 Exerts a negative regulation on the expression of XIAP protein products Edited XIAP suppressed the XIAP-dependent apoptotic response
  • ADAR1
 A-to-I UTR3 chrX:123046689 mRNA expression change Presence brain NA mRNA expression change RNA editing could contribute towards aberrant synaptic formation in ASD