EDK
Editome Disease Knowledgebase
has-mir-149
| miRNA ID | has-mir-149 | Editing sites | 1 |
|---|---|
| Species | Human |
| miRBase | |
| PMID | |
| Description | ADAR1p150 can promote the biosynthesis and function of miRNA-149* in melanoma cells which makes it be considered as both a bio-marker and a therapeutic target for treatment of melanoma. |
| Disease | Melanoma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Regulation Target | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Increase | miRNA and its target gene expression change | ADAR1p150 expression was negatively correlated with the expression of GSK3α | Correlated | Positive | ADAR1p150 expression was negatively correlated with the expression of GSK3α | miRNA-149 is considered as both a bio-marker and a therapeutic target for treatment of melanoma | 31959472 |