EDK
Editome Disease Knowledgebase
hsa-let-7a-1
| miRNA ID | hsa-let-7a-1 | Editing sites | 2 |
|---|---|
| Species | Human |
| miRBase | MI0000060 |
| PMID | 27494666;27292188 |
| Description | ADAR1 regulates let-7 miRNA biogenesis in an A-to-I editing dependent manner, it promotes the self-renewal and survival capability of chronic myeloid leukemia Leukemic stem cells. |
| Disease | Chronic Myeloid Leukemia; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Increase | Causative | Negative | RNA editing promotes the self-renewal and survival capability of chronic myeloid leukemia Leukemic stem cells. | Promote survival capability | 27494666;27292188 | |
| ADAR1 | A-to-G | Increase | Causative | Negative | RNA editing promotes the self-renewal and survival capability of chronic myeloid leukemia Leukemic stem cells. | Promote survival capability | 27494666;27292188 |