EDK
Editome Disease Knowledgebase
hsa-miR-376a
| miRNA ID | hsa-miR-376a | Editing sites | 1 |
|---|---|
| Species | Human |
| miRBase | MI0000784 |
| PMID | 23093778 |
| Description | ADAR1 regulates let-7 miRNA biogenesis in an A-to-I editing dependent manner, it promotes the self-renewal and survival capability of chronic myeloid leukemia Leukemic stem cells. |
| Disease | Glioma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Target Change | Regulation Target | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Increase | Retargeting of miRNA | RAP2A->AMFR | Retarget AMFR combined with inhibit the original target RAP2A expression | Correlated | Positive | A low editing level of miR-376a increases the migration ability of tumor cells and is associated with more aggressive tumors. | Promote tumor migration and invasion | 23093778 |