EDK
Editome Disease Knowledgebase
hsa-miR-378a-3p
| miRNA ID | hsa-miR-378a-3p | Editing sites | 1 |
|---|---|
| Species | Human |
| miRBase | MIMAT0000732 |
| PMID | 29386624 |
| Description | The edited form of miR-378a-3p preferentially binds to the 3'UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. |
| Disease | Melanoma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Target Change | Regulation Target | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Increase | Target gene expression change | PARVA->PARVA | Inhibit PARVA expression | Causative | Positive | The edited miR-378a-3p prevents the progression of melanoma towards the malignant phenotype. | Inhibit tumor progression | 29386624 |