EDK
Editome Disease Knowledgebase
hsa-miR-455-5p
| miRNA ID | hsa-miR-455-5p | Editing sites | 2 |
|---|---|
| Species | Human |
| miRBase | MI0003513 |
| PMID | 25686251 |
| Description | miR-455-5p has two A-to-I RNA editing sites, one at mature position 2 and one at mature position 17 The biological function of edited miR-455-5p is different from the unedited form as it recognizes a different set of genes. miR-455-5p promotes melanoma metastasis via inhibition of the tumor suppressor gene CPEB1. Moreover, miR-455 enhances melanoma growth and metastasis in vivo while the edited form inhibits these features. |
| Disease | Melanoma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Target Change | Regulation Target | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Absent | Target gene expression change | CPEB1->CPEB1 | Inhibit tumor suppressor gene CPEB1 | Causative | Negative | miR-455 enhances melanoma growth and metastasis in vivo while the edited form inhibits these features. | Inhibit tumor growth and metastasis | 25686251 | |
| ADAR1 | A-to-G | Absent | Target gene expression change | CPEB1->CPEB1 | Inhibit tumor suppressor gene CPEB1 | Causative | Negative | miR-455 enhances melanoma growth and metastasis in vivo while the edited form inhibits these features. | Inhibit tumor growth and metastasis | 25686251 |