EDK Editome Disease Knowledgebase

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Epilepsy is a group of neurological disorders characterized by epileptic seizures. Epileptic seizures are episodes that can vary from brief and nearly undetectable periods to long periods of vigorous shaking. These episodes can result in physical injuries, including occasionally broken bones.

Huntington's disease, also known as Huntington's chorea, is an inherited disorder that results in death of brain cells.

A central nervous system disease that results in the progressive deterioration of function or structure of neurons.

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A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

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Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.

The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes. They are: behavioral variant of FTD, semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.

Progressive supranuclear palsy is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.

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A spinal cord injury is damage to the spinal cord that causes temporary or permanent changes in its function.