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Zika virus - ZIKV

Virus Host Enzyme Edited Genes Phenotype Disease Details
Zika virus Human ADAR Host glutamate receptors Antiviral Guillain-Barré syndrome
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: NA
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Negative
  • Description: The authors collect and synthesize existing evidence of ZIKV-mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies.
  • PMID: 31106880
Zika virus Human ADAR NA Mutational Pressure Guillain-Barré syndrome
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: NA
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Negative
  • Description: Results showed that guanine usage is growing in ZIKV RNA plus strand due to adenine to guanine transitions, while adenine usage is growing due to cytosine to adenine transversions. Especially high levels of guanine have been found in two-fold degenerated sites of certain areas of RNA plus strand with high amount of secondary structure. The usage of cytosine in two-fold degenerated sites shows direct dependence on the amount of secondary structure in 52% (consensus sequence of East African ZIKV lineage)-32% (consensus sequence of epidemic strains) of the length of RNA minus strand. These facts are the evidences of ADAR-editing of both strands of ZIKV genome during pauses in replication. RNA plus strand can also be edited by ADAR during pauses in translation caused by the appearance of groups of rare codons. According to our results, RNA minus strand of epidemic ZIKV strain has lower number of points in which polymerase can be stalled (allowing ADAR-editing) compared to other strains.
  • PMID: 28275585