EDK Editome Disease Knowledgebase

  1. Home
  2. Editing Dependent Virus
  3. Human Papillomavirus

Human Papillomavirus - HPV

Virus Host Enzyme Edited Genes Phenotype Disease Details
Human Papillomavirus Human APOBEC3A E2 gene Antiviral Cervical cancer
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: G-to-A; C-to-U
  • Amino Acid Change: NA
  • Editing Level: Increase
  • Molecular Consequence: NA
  • Correlation: Positive
  • Description: Heat treatment resulted in elevated expression of A3A and A3G in a temperature-dependent manner in HPV-infected cells. Correspondingly, HPV-infected cells heat-treated at 44 °C showed accumulated G-to-A or C-to-T mutation in HPV E2 gene. Knockdown of A3A or A3G could promote cell viability, along with the lower frequency of A/T in HPV E2 gene. In addition, regressing genital viral warts also harbored high G-to-A or C-to-T mutation in HPV E2 gene. Taken together, we demonstrate that apolipoprotein B mRNA-editing catalytic polypeptide 3 expression and editing function was heat sensitive to a certain degree, partly explaining the mechanism of action of local hyperthermia to treat viral warts.
  • PMID: 27890786
Human Papillomavirus Human APOBEC3G E2 gene Antiviral Cervical cancer
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: G-to-A; C-to-U
  • Amino Acid Change: NA
  • Editing Level: Increase
  • Molecular Consequence: NA
  • Correlation: Positive
  • Description: Heat treatment resulted in elevated expression of A3A and A3G in a temperature-dependent manner in HPV-infected cells. Correspondingly, HPV-infected cells heat-treated at 44 °C showed accumulated G-to-A or C-to-T mutation in HPV E2 gene. Knockdown of A3A or A3G could promote cell viability, along with the lower frequency of A/T in HPV E2 gene. In addition, regressing genital viral warts also harbored high G-to-A or C-to-T mutation in HPV E2 gene. Taken together, we demonstrate that apolipoprotein B mRNA-editing catalytic polypeptide 3 expression and editing function was heat sensitive to a certain degree, partly explaining the mechanism of action of local hyperthermia to treat viral warts.
  • PMID: 27890786