EDK Editome Disease Knowledgebase

  1. Home
  2. Editing Independent Virus
  3. Hepatitis C virus

Hepatitis C virus - HCV

Virus Host Enzyme Phenotype Disease Details
Hepatitis C virus Human ADAR1 Inhibit viral replication Hepatitis
  • Correlation: Negative
  • Description: Small inhibitory RNA, specific for ADAR1, stimulated the replicon 40-fold, indicating that ADAR1 has a role in limiting replication of the viral RNA.
  • PMID: 15858013
Hepatitis C virus Human APOBEC3G Increased expression of the editing enzyme Hepatitis
  • Correlation: Negative
  • Description: Transfection of the NS5A gene, but not any other non-structural protein genes of HCV tested, to the hepatocellular carcinoma cell line enhanced APOBEC3G expression.
  • PMID: 17036163
Hepatitis C virus Human APOBEC3G Inhibit viral replication Hepatitis
  • Correlation: Negative
  • Description: Introduction of external hA3G into HCV-infected Huh7.5 human hepatocytes inhibited HCV replication; knockdown of endogenous hA3G enhanced HCV replication. Exogenous HIV-1 virion infec- tivity factor (Vif) decreased intracellular hA3G and therefore enhanced HCV proliferation, suggesting that the presence of Vif might be an explanation for the HIV-1/HCV coinfection often observed in HIV-1(1) individuals.
  • PMID: 21480314
Hepatitis C virus Human; Mice APOBEC3 Antiviral Hepatitis
  • Correlation: Negative
  • Description: The researchers developed TCR-reprogrammed nonlytic T cells capable of activating APOBEC3 in hepatoma cells and in HBV-infected human hepatocytes in mice, limiting viral infection. These cells with limited hepatotoxicity might be developed for treatment of chronic HBV infection.
  • PMID: 29550589
Hepatitis C virus Human APOBEC3 Antiviral Hepatitis
  • Correlation: Negative
  • Description: The virus produced by APOB KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wild-type virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus.
  • PMID: 28018102