Virus - EDK - BIG Data Center

Abbr: HCMV
Classification: dsDNA
Protein Sequence: protein RL1; protein RL5A; protein RL6; protein RL8A; protein RL9A; envelope glycoprotein RL10; membrane glycoprotein RL11; membrane protein RL12; membrane protein RL13; membrane protein UL1; protein UL2; envelope glycoprotein UL4; protein UL5; membrane protein UL6; membrane glycoprotein UL8; membrane glycoprotein UL7; membrane protein UL10; membrane glycoprotein UL11; protein UL13; membrane protein UL14; protein UL15A; membrane glycoprotein UL16; protein UL17; membrane glycoprotein UL18; protein UL19; membrane protein UL20; protein UL21A; glycoprotein UL22A; tegument protein UL23; tegument protein UL24; tegument protein UL25; tegument protein UL26; protein UL27; protein UL29; protein UL30; protein UL30A; protein UL31; tegument protein pp150; envelope glycoprotein UL33; protein UL34; tegument protein UL35; tegument protein vICA; envelope glycoprotein UL37; protein UL38; membrane glycoprotein UL40; protein UL41A; protein UL42; tegument protein UL43; DNA polymerase processivity subunit; ribonucleotide reductase subunit 1; capsid triplex subunit 1; tegument protein UL37; large tegument protein; small capsid protein; protein UL49; nuclear egress membrane protein; DNA packaging protein UL33; DNA packaging protein UL32; nuclear egress lamina protein; DNA polymerase catalytic subunit; envelope glycoprotein B; DNA packaging terminase subunit 2; single-stranded DNA-binding protein; multifunctional expression regulator; helicase-primase primase subunit; tegument protein UL51; deoxyuridine triphosphatase; envelope glycoprotein N; envelope glycoprotein O; envelope glycoprotein 24; envelope glycoprotein H; nuclear protein UL24; DNA packaging tegument protein UL25; envelope protein UL78; protein UL79; capsid maturation protease; capsid scaffold protein; tegument protein pp71; tegument protein pp65; protein UL84; capsid triplex subunit 2; major capsid protein; protein UL87; tegument protein UL88; DNA packaging terminase subunit 1; protein UL91; protein UL92; DNA packaging tegument protein UL17; tegument protein UL16; protein UL95; tegument protein UL14; tegument serine/threonine protein kinase; deoxyribonuclease; myristylated tegument protein; envelope glycoprotein M; helicase-primase subunit; tegument protein UL7; capsid portal protein; helicase-primase helicase subunit; interleukin-10; protein UL112; uracil-DNA glycosylase; envelope glycoprotein L; protein UL116; protein UL117; membrane glycoprotein UL119; membrane protein UL120; membrane protein UL121; regulatory protein IE2; regulatory protein IE1; membrane protein UL124; envelope glycoprotein UL130; envelope protein UL131A; envelope glycoprotein UL132; membrane protein UL148; membrane protein UL147A; chemokine vCXCL2; chemokine vCXCL1; protein UL145; membrane glycoprotein UL144; membrane glycoprotein UL142; membrane glycoprotein UL141; protein UL140; membrane glycoprotein UL139; protein UL138; protein UL136; protein UL135; protein UL133; protein UL148A; protein UL148B; protein UL148C; protein UL148D; protein UL150; protein UL150A; tegument protein IRS1; protein US1; membrane glycoprotein US2; membrane glycoprotein US3; membrane glycoprotein US6; membrane glycoprotein US7; membrane glycoprotein US8; membrane glycoprotein US9; membrane glycoprotein US10; membrane glycoprotein US11; membrane protein US12; membrane protein US13; membrane protein US14; membrane protein US15; membrane protein US16; membrane protein US17; membrane protein US18; membrane protein US19; membrane protein US20; membrane protein US21; membrane protein US22; membrane protein US23; membrane protein US24; membrane protein US26; membrane protein US27; membrane protein US28; membrane protein US29; membrane protein US30; protein US31; protein US32; protein US33; protein US34; tegument protein TRS1
Summary: HCMV has evolved mutational robustness against IFN-β by limiting the presence of A3G hot spots in essential open reading frames (ORFs) of its genome

Virus	Host	Enzyme	Edited Genes	Phenotype	Disease	Details
Human cytomegalovirus	Human	APOBEC3G	NA	Antiviral	Symptomatic diseases
Edited Gene Alias: NA Editing Site: NA Editing Type: NA Amino Acid Change: NA Editing Level: Present Molecular Consequence: NA Correlation: Negative Description: APOBEC3G (A3G) gene products and, to a lesser degree, those of A3F but not of A3A, are upregulated in HCMV-infected HFFs. We also show that HCMV-mediated induction of A3G expression is mediated by interferon beta (IFN-β), which is produced early during HCMV infection. However, knockout or overexpression of A3G does not affect HCMV replication, indicating that A3G is not a restriction factor for HCMV. Finally, through a bioinformatics approach, we show that HCMV has evolved mutational robustness against IFN-β by limiting the presence of A3G hot spots in essential open reading frames (ORFs) of its genome. Overall, our findings uncover a novel immune evasion strategy by HCMV with profound implications for HCMV infections. PMID: 30045985

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Human cytomegalovirus - HCMV