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Influenza A - NA

Virus Host Enzyme Edited Genes Phenotype Disease Details
Influenza A Human ADAR1 NS1 Promote viral replication Influenza
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: A-to-I
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: Influenza virus proteins
  • Correlation: Negative
  • Description: ADAR1 editing activity was enhanced by both viruses through influenza virus NS1 proteins, suggesting a similar virus-host co-evolution.
  • PMID: 23853584
Influenza A Human ADAR1 NS1 Promote viral replication Influenza
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: A-to-I
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: Inhibit antiviral activity
  • Correlation: Negative
  • Description: Increasing amounts of both long (150 kDa) and short (110 kDa) forms of ADAR1 were seen in the nucleolar fraction from Influenza A virus(IAV) infected cells. Genetic studies in mice infected with IAV indicated that ADAR1 can edit at least one of the viral mRNAs and may be part of an antiviral response.It is therefore tempting to speculate that sequestration of ADAR1 to the nucleolus in influenza virus infected cells is a mechanism to mitigate its antiviral activity.
  • PMID: 20701360