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Measles virus - MV

Virus Host Enzyme Edited Genes Phenotype Disease Details
Measles virus Human ADAR1p150 NA Proviral Fever; Upper respiratory discomfort
  • Edited Gene Alias: NA
  • Editing Site: NA
  • Editing Type: A-to-I
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Positive
  • Description: Whereas ADAR1p150 rarely edits tightly encapsidated standard measles virus (MeV) genomes, it efficiently edits genomes with inverted repeats accidentally generated by a mutant MeV. We also show that immune activation occurs in fully ADAR1-deficient (ADAR1KO) cells, restricting virus growth, and that complementation of these cells with ADAR1p150 rescues virus growth and suppresses innate immunity activation.
  • PMID: 30496178
Measles virus Human NA phosphoprotein gene Produce new protein Fever; Upper respiratory discomfort
  • Edited Gene Alias: P gene
  • Editing Site: NA
  • Editing Type: G insertion
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Negative
  • Description: The V protein is synthesized by pseudo-templated transcription, also designated as RNA editing: during P gene transcription one G residue is inserted at a defined position in about 50% of the mRNAs
  • PMID: 9018130
Measles virus Hamster NA Phosphoprotein (P) gene Antiviral Fever; Upper respiratory discomfort
  • Edited Gene Alias: P gene
  • Editing Site: NA
  • Editing Type: G insertion
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Negative
  • Description: Editing of P mRNA in the neurotropic strains shows a shift away from the single G insertion product to those with greater than 2 Gs inserted.
  • PMID: 7886959
Measles virus Human NA Phosphoprotein (P) gene Produce new protein Fever; Upper respiratory discomfort
  • Edited Gene Alias: P gene
  • Editing Site: NA
  • Editing Type: G insertion
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: Positive
  • Description: A transcription system with detergent-disrupted purified measles virus which we used to demonstrate the synthesis of both viral mRNA sand free leader RNA in vitro,suggesting that the mechanism of viral transcription is an alogousto that of other negative-strand RNA viruses. Furthermore, we showed that measles virus PmRNA editing occurs during in vitro transcription with purified virus.
  • PMID: 1895388