Another Name: Plasma Thromboplastin Antecedent Deficiency
Disease Description: A rare clotting disorder of several dog breeds. Protracted bleeding from surgical procedures is a feature. Affects both sexes.
Inherit Mode: autosomal-recessive
Disease Symptom: If the puppy survives into adulthood, he may still exhibit intermittent episodes of bleeding. Other symptoms of hemophilia in dogs include the following:Bleeding from the mouth;Skin hematomas;Swelling in joints or muscles;Lameness;Red spots on the skin;Discolored skin;Nose bleeds;Bloody stools;Weakness
Disease Cause: Factor XI deficiency is an autosomal-recessive, genetically inherited form of hemophilia and it most frequently presents as delayed hemorrhage up to several days after a surgery or trauma.
Disease Diagnose: Diagnosis of hemophilia is fairly simple because it generally causes prolonged or severe bleeding. In the case of hemophilia C, however, it is often delayed and may occur without warning. In fact, you probably won’t even know that your dog has the deficiency until he starts to bleed. There is no cure for hemophilia in dogs and blood transfusions are among the only options for treatment.
Treat Method: When hemophilia affects puppies to the point that they display symptoms, recovery is usually poor – internal bleeding is a common problem and can be lethal at this age. In older dogs, uncontrolled bleeding can also be fatal but there may be a little more time to seek treatment. If your dog exhibits intermittent bleeding episodes, you may learn to identify the signs but, in many cases, hemophilia C comes on quickly and, because it is so rare, you may not even know to look for it.Unfortunately, the only way to prevent the disease is to avoid breeding dogs that are affected. In the case of hemophilia C, however, you may not know the dog has the deficiency until it has an episode, and, at that point, it may already be too late. If your dog is one of the breeds mentioned, you may want to talk to your veterinarian about testing for the condition just to be safe.
Breeder Advice: -
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Factor XI deficiency | - | Autosomal | F11 |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB98 | English Toy Spaniel | Affectionate, Alert, Merry | 22.9-25.4 cm | 3.6-6.4 kg | England |
CB121 | Greater Swiss Mountain Dog | Faithful, dependable, family oriented; Swissies are famously even-tempered | 64.8-72.4 cm (male), 60.2-68.6 cm (female) | 52.2-63.5 kg (male), 38.6-49.9 kg (female) | Switzerland |
CB143 | Kishu Inu(Kishu Ken) | Faithful, Noble, Docile | 52cm (male) 49cm (female) | 13.6-27.2kg | Japan |
2006 |
Tcherneva,E.,Huff,A.M.,Giger,U.: :
Coagulation factor XI deficiency in Kerry blue terrier dogs is caused by an exonic sine insertion Journal of Veterinary Internal Medicine 20:767 only, 2006. |
1994 |
Knowler,C.,Giger,U.,Dodds,W.J.,Brooks,M.: :
Factor XI deficiency in Kerry Blue Terriers Journal of the American Veterinary Medical Association 205:1557-1561, 1994. Pubmed reference: 7730123 . |
1988 |
Fogh,J.M.,Fogh,I.T.: :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988. Pubmed reference: 3282382 . |
1974 |
Dodds,W.J.: :
Hereditary and acquired hemorrhagic disorders in animals. Prog Hemost Thromb 2:215-47, 1974. Pubmed reference: 4604529 . |
1971 |
Dodds,W.J.,Kull,J.E.: :
Canine factor XI (plasma thromboplastin antecedent) deficiency. J Lab Clin Med 78:746-52, 1971. Pubmed reference: 5166932 . |