The detail information of Factor XII deficiency
Basic Information

Disease Description: A clotting factor deficiency that rarely produces clinical signs. Seen in toy and standard poodles and occasionally in other breeds. Usually diagnosed incidentally during blood testing for potential bleeding disorder.

Inherit Mode: -

Disease Symptom: Affected dogs are usually asymptomatic, although a predisposition to thromboembolism is possible. In some dogs, occasional bouts of hematochezia and diarrhea may be confused with ulcerative colitis, and occasional hematoma formation has been observed in otherwise asymptomatic dogs.Urinalysis may reveal intermittent hematuria

Disease Cause: -

Disease Diagnose: The condition is usually diagnosed incidentally during routine coagulation screening test, which shows prolonged partial thromboplastin and activated clotting times, but normal thrombin clotting time and fibrinogen concentration.

Treat Method: -

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Factor XII deficiency - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB21 Basset Fauve de Bretagne(Fawn Brittany Basset) Smart, Cheerful, Determined 32–38 cm (13–15 in) France
CB269 Standard Poodle Intelligent and quick-to-please 56-66 cm
CB270 Toy Poodle Intelligent, eager to please, quick to learn and an affectionate, loyal pet. under 25 cm
References
2000 Lutze,G.,Kutschmann,K.,Aumann,V.,Hartung,K.J.,Mittler,U.: :
Combined von Willebrand disease and factor XII deficiency (vWD San Diego) in the dog and humans [German] Praktische Tierarzt 81:912-+, 2000.
1991 Otto,C.M.,Dodds,W.J.,Greene,C.E.: :
Factor-XII and Partial Prekallikrein Deficiencies in a Dog with Recurrent Gastrointestinal Hemorrhage Journal of the American Veterinary Medical Association 198:129-131, 1991.
Pubmed reference: 1995570 .
1988 Fogh,J.M.,Fogh,I.T.: :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988.
Pubmed reference: 3282382 .
1986 Randolph,J.F.,Center,S.A.,Dodds,W.J.: :
Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs. Cornell Vet 76:3-10, 1986.
Pubmed reference: 3484442 .
1974 Dodds,W.J.: :
Hereditary and acquired hemorrhagic disorders in animals. Prog Hemost Thromb 2:215-47, 1974.
Pubmed reference: 4604529 .