The detail information of Syringomyelia
Basic Information
Disease Description: Developmental abnormalities causing cavities within the spinal cord, probably just an effect of #289. Common in Rhodesian ridgebacks.
Inherit Mode: -
Disease Symptom: Clinical signs include progressive weakness in the forelimbs and episodes of involuntary scratching of the flank. The dog's forelimbs would slide on a slippery surface and he would be unable to correct this posture. Since the spinal cord connects the brain to the nerves in the extremities, this damage may result in pain, weakness, and stiffness in the back or legs.
Disease Cause: Syringomyelia may result from a congenital defect of the neural tube or trauma to the spinal cord, such as a car accident or serious fall.
Disease Diagnose: The syrinx is diagnosed using an MRI test.
Treat Method: With increasing use of MRI and increased awareness of syringomyelia complex, early detection may enable surgical resolution of this potentially debilitating neurological disease. Further studies may also shed light on the heritability of this disease, as it has been reported as a genetic disorder in the King Charles Spaniel. In this breed, syringomyelia occurs as a result of inherited occipital hypoplasia/Chiari type I malformation.
Breeder Advice: -
Disease Description Source: Link
Associated Diseases
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Syringomyelia | - | Multifactorial | - |
Associated Breeds
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB252 | Weimaraner | Friendly, fearless, alert, obedient | 63.5-68.6 cm (male), 58.4-63.5 cm (female) | 31.8-40.8 kg (male), 24.9-34 kg (female) | Germany |
| CB253 | Welsh Springer Spaniel | Happy, upbeat, family oriented; reserved but not shy with strangers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 18.1-24.9 kg (male), 15.9-22.7 kg (female) | United Kingdom (Wales) |
References
| 2021 |
Mondino,A.,Delucchi,L.,Moeser,A.,Cerdá-González,S.,Vanini,G.: :
Sleep Disorders in dogs: A Pathophysiological and Clinical Review. Top Companion Anim Med 43:100516, 2021. Pubmed reference: 33556640 . DOI: 10.1016/j.tcam.2021.100516 . |
| 2019 |
Thoefner,M.S.,Westrup,U.,Toft,N.,Bjerrum,O.J.,Berendt,M.: :
Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs. Vet J 246:92-97, 2019. Pubmed reference: 30902196 . DOI: 10.1016/j.tvjl.2019.01.011 . |
| 2017 |
Knowler,S.P.,Kiviranta,A.M.,McFadyen,A.K.,Jokinen,T.S.,LaRagione,R.M.,Rusbridge,C.: :
Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation. PLoS One 12:e0169898, 2017. Pubmed reference: 28121988 . DOI: 10.1371/journal.pone.0169898 . |
| 2017 |
Wijnrocx,K.,VanBruggen,L.W.L.,Eggelmeijer,W.,Noorman,E.,Jacques,A.,Buys,N.,Janssens,S.,Mandigers,P.J.J.: :
Twelve years of chiari-like malformation and syringomyelia scanning in Cavalier King Charles Spaniels in the Netherlands: Towards a more precise phenotype. PLoS One 12:e0184893, 2017. Pubmed reference: 28934242 . DOI: 10.1371/journal.pone.0184893 . |
| 2015 |
Thøfner,M.S.,Stougaard,C.L.,Westrup,U.,Madry,A.A.,Knudsen,C.S.,Berg,H.,Jensen,C.S.,Handby,R.M.,Gredal,H.,Fredholm,M.,Berendt,M.: :
Prevalence and Heritability of Symptomatic Syringomyelia in Cavalier King Charles Spaniels and Long-term Outcome in Symptomatic and Asymptomatic Littermates. J Vet Intern Med 29:243-250, 2015. Pubmed reference: 25308931 . DOI: 10.1111/jvim.12475 . |
| 2015 |
Wrzosek,M.,Płonek,M.,Nicpoń,J.,Cizinauskas,S.,Pakozdy,A.: :
Retrospective multicenter evaluation of the "fly-catching syndrome" in 24 dogs: EEG, BAER, MRI, CSF findings and response to antiepileptic and antidepressant treatment. Epilepsy Behav 53:184-9, 2015. Pubmed reference: 26584225 . DOI: 10.1016/j.yebeh.2015.10.013 . |
| 2014 |
Knowler,S.P.,McFadyen,A.K.,Freeman,C.,Kent,M.,Platt,S.R.,Kibar,Z.,Rusbridge,C.: :
Quantitative analysis of Chiari-like malformation and syringomyelia in the Griffon Bruxellois dog. PLoS One 9:e88120, 2014. Pubmed reference: 24533070 . DOI: 10.1371/journal.pone.0088120 . |
| 2014 |
Mitchell,T.J.,Knowler,S.P.,vandenBerg,H.,Sykes,J.,Rusbridge,C.: :
Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog. Canine Genet Epidemiol 1:9, 2014. Pubmed reference: 26401326 . DOI: 10.1186/2052-6687-1-9 . |
| 2013 |
Driver,C.J.,Watts,V.,Bunck,A.C.,VanHam,L.M.,Volk,H.A.: :
Assessment of cerebellar pulsation in dogs with and without Chiari-like malformation and syringomyelia using cardiac-gated cine magnetic resonance imaging. Vet J :, 2013. Pubmed reference: 23770398 . DOI: 10.1016/j.tvjl.2013.05.017 . |
| 2013 |
Fenn,J.,Schmidt,M.J.,Simpson,H.,Driver,C.J.,Volk,H.A.: :
Venous sinus volume in the caudal cranial fossa in Cavalier King Charles spaniels with syringomyelia. Vet J :, 2013. Pubmed reference: 23755937 . DOI: 10.1016/j.tvjl.2013.05.007 . |
| 2011 |
Knowler,S.P.,McFadyen,A.K.,Rusbridge,C.: :
Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia. Vet Rec :, 2011. Pubmed reference: 21998144 . DOI: 10.1136/vr.100062 . |
| 2011 |
Parker,J.E.,Knowler,S.P.,Rusbridge,C.,Noorman,E.,Jeffery,N.D.: :
Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels. Vet Rec 168:667, 2011. Pubmed reference: 21672954 . DOI: 10.1136/vr.d1726 . |
| 2010 |
Lewis,T.,Rusbridge,C.,Knowler,P.,Blott,S.,Woolliams,JA.: :
Heritability of syringomyelia in Cavalier King Charles spaniels. Vet J 183:345-7, 2010. Pubmed reference: 19914109 . DOI: 10.1016/j.tvjl.2009.10.022 . |
| 2010 |
Wolfe,KC.,Poma,R.: :
Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog. Can Vet J 51:95-102, 2010. Pubmed reference: 20357949 . |
| 2009 |
Carruthers,H.,Rusbridge,C.,Dubé,M.P.,Holmes,M.,Jeffery,N.: :
Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 50:394-8, 2009. Pubmed reference: 19689666 . DOI: 10.1111/j.1748-5827.2009.00768.x . |
| 2009 |
Cerda-Gonzalez,S.,Olby,NJ.,Broadstone,R.,McCullough,S.,Osborne,JA.: :
Characteristics of cerebrospinal fluid flow in Cavalier King Charles Spaniels analyzed using phase velocity cine magnetic resonance imaging. Vet Radiol Ultrasound 50:467-76, 2009. Pubmed reference: 19788029 . |
| 2009 |
Mandigers,P.,Rusbridge,C.: :
[Chiari-like malformation--syringomyelia in the Cavalier King Charles Spaniel] Tijdschr Diergeneeskd 134:746-50, 2009. Pubmed reference: 19911737 . |
| 2009 |
Park,C.,Kang,BT.,Yoo,JH.,Park,HM.: :
Syringomyelia in three small breed dogs secondary to Chiari-like malformation: clinical and diagnostic findings. J Vet Sci 10:365-7, 2009. Pubmed reference: 19934606 . |
| 2009 |
Rusbridge,C.,Knowler,SP.,Pieterse,L.,McFadyen,AK.: :
Chiari-like malformation in the Griffon Bruxellois. J Small Anim Pract 50:386-93, 2009. Pubmed reference: 19689665 . DOI: 10.1111/j.1748-5827.2009.00744.x . |
| 2008 |
Chandler,K.,Volk,H.,Rusbridge,C.,Jeffery,N.: :
Syringomyelia in cavalier King Charles spaniels. Vet Rec 162:324, 2008. Pubmed reference: 18326849 . |
| 2008 |
Kitagawa,M.,Ueno,H.,Watanabe,S.,Igarashi,O.,Uzuka,Y.,Kanayama,K.,Sakai,T.: :
Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J 86:36-42, 2008. Pubmed reference: 18271823 . DOI: 10.1111/j.1751-0813.2007.00247.x . |
| 2008 |
Rusbridge,C.,Jeffery,ND.: :
Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J 175:164-72, 2008. Pubmed reference: 17317245 . DOI: 10.1016/j.tvjl.2006.12.007 . |
| 2008 |
Stalin,CE.,Rusbridge,C.,Granger,N.,Jeffery,ND.: :
Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res 69:89-93, 2008. Pubmed reference: 18167092 . DOI: 10.2460/ajvr.69.1.89 . |
| 2007 |
Rusbridge,C.,Carruthers,H.,Dubé,M.P.,Holmes,M.,Jeffery,N.D.: :
Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract 48:432-6, 2007. Pubmed reference: 17608656 . DOI: 10.1111/j.1748-5827.2007.00344.x . |
| 2006 |
Jung,DI.,Park,C.,Kang,BT.,Kim,JW.,Kim,HJ.,Lim,CY.,Jeong,SW.,Park,HM.: :
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci 68:1235-8, 2006. Pubmed reference: 17146188 . |
| 2006 |
MacKillop,E.,Schatzberg,SJ.,deLahunta,A.: :
Intracranial epidermoid cyst and syringohydromyelia in a dog. Vet Radiol Ultrasound 47:339-44, 2006. Pubmed reference: 16863050 . |
| 2006 |
Rusbridge,C.,Greitz,D.,Iskandar,BJ.: :
Syringomyelia: current concepts in pathogenesis, diagnosis, and treatment. J Vet Intern Med 20:469-79, 2006. Pubmed reference: 16734077 . |
| 2006 |
Rusbridge,C.,Knowler,SP.: :
Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 47:603-6, 2006. Pubmed reference: 17004953 . DOI: 10.1111/j.1748-5827.2006.00048.x . |
| 2005 |
Hasegawa,T.,Taura,Y.,Kido,H.,Shibazaki,A.,Katamoto,H.: :
Surgical management of combined hydrocephalus, syringohydromyelia, and ventricular cyst in a dog. J Am Anim Hosp Assoc 41:267-72, 2005. Pubmed reference: 15995165 . |
| 2005 |
Rusbridge,C.,Knowler,P.,Rouleau,GA.,Minassian,BA.,Rothuizen,J.: :
Inherited occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel: experiences in setting up a worldwide DNA collection. J Hered 96:745-9, 2005. Pubmed reference: 15958797 . DOI: 10.1093/jhered/esi074 . |
| 2005 |
Takagi,S.,Kadosawa,T.,Ohsaki,T.,Hoshino,Y.,Okumura,M.,Fujinaga,T.: :
Hindbrain decompression in a dog with scoliosis associated with syringomyelia. J Am Vet Med Assoc 226:1359-63, 1347, 2005. Pubmed reference: 15844429 . |
| 2004 |
Rusbridge,C.,Knowler,SP.: :
Inheritance of occipital bone hypoplasia (Chiari type I malformation) in Cavalier King Charles Spaniels. J Vet Intern Med 18:673-8, 2004. Pubmed reference: 15515584 . |
| 2000 |
Bagley,R.S.,Gavin,P.R.,Silver,G.M.,Moore,M.P.,Kippenes,H.,Connors,R.: :
Syringomyelia and hydromyelia in dogs and cats Compendium on Continuing Education for the Practicing Veterinarian 22:471-479, 2000. |
| 2000 |
Rusbridge,C.,MacSweeny,J.E.,Davies,J.V.,Chandler,K.,Fitzmaurice,S.N.,Dennis,R.,Cappello,R.,Wheeler,S.J.: :
Syringohydromyelia in Cavalier King Charles spaniels Journal of the American Animal Hospital Association 36:34-41, 2000. Pubmed reference: 10667404 . |
| 2000 |
Taga,A.,Taura,Y.,Nakaichi,M.,Wada,N.,Hasegawa,T.: :
Magnetic resonance imaging of syringomyelia in five dogs Journal of Small Animal Practice 41:362-365, 2000. Pubmed reference: 11002940 . |
| 1996 |
Itoh,T.,Nishimura,R.,Matsunaga,S.,Kodosawa,T.,Mochizuki,M.,Sasaki,N.: :
Syringomyelia and hydrocephalus in a dog Journal of the American Veterinary Medical Association 209:934 ff., 1996. |
| 1973 |
Furneaux,R.W.,Doige,C.E.,Kaye,M.M.: :
Syringomyelia and spina bifida occulta in a Samoyed dog. Can Vet J 14:317-21, 1973. Pubmed reference: 4588835 . |
| 1965 |
McGrath,J.T.: :
Spinal dysraphism in the dog, with comments on syringomylia Pathologia Veterinaria 2:1-36 (Supplement), 1965. Pubmed reference: 5893238 . |