Another Name: Blue Doberman Syndrome
Disease Description: A condition where certain colored areas of a dog's skin grows less or no fur. Commonly seen in Yorkshire terriers, blue Doberman pinschers and fawn Irish setters.
Inherit Mode: -
Disease Symptom: Affected dogs are born with a healthy hair coat. At 6 months of age or later, the coat becomes thin, brittle, and dry and takes on a moth-eaten appearance. The skin becomes rough and scaly. Blackheads, pimples, and pustules (puss filled pimples) appear on the involved areas.
Disease Cause: The coat mutation has a genetic basis.
Disease Diagnose: Diagnosis is made by physical exam.
Treat Method: Treatment is directed toward relieving the surface condition, which involves shampoos that rehydrate the skin, remove scales, and flush the hair follicles. These must be prescribed by your vet. Because the affected hair is fragile and comes out easily, vigorous brushing and the use of harsh or inappropriate shampoos aggravates the problem and should be avoided.
Breeder Advice: Affected dogs should not be bred.
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Coat colour, dilution, MLPH-related | Colour mutant alopecia; Color dilution alopecia; Colour dilution alopecia | Autosomal Recessive | MLPH |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB76 | Cirneco dell'Etna | Affectionate, Friendly, Independent | 18-19.5 inches (male), 16.5-18 inches (female) | 22-26 pounds (male), 17-22 pounds (female) | Italy |
CB89 | Dogo Argentino | Loyal, trustworthy,courageous | 61-68.6 cm (male), 59.7-66 cm (female) | 36.3-45.4 kg | Argentina |
CB97 | English Springer Spaniel | Friendly, playful, obedient at home; hardworking and steady in the field | 50.8 cm (male), 48.3 cm (female) | 22.7 kg (male), 18.1 kg (female) | United Kingdom (England) |
CB120 | Great Pyrenees | Calm, patient, smart; strong-willed yet affectionate | 68.6-81.3 cm (male), 63.5-73.7 cm (female) | 45.4 kg & up (male), 38.6 kg & up (female) | France, Spain |
CB132 | Irish Terrier | Bold, dashing, even reckless; stouthearted at work, tenderhearted at home | 45.7 cm | 12.2 kg (male), 11.3 kg (female) | Ireland |
CB136 | German Jagdterrier | Courageous, Intelligent, Hardworking | 33-40cm | 7.7-9.9kg | Germany |
CB253 | Welsh Springer Spaniel | Happy, upbeat, family oriented; reserved but not shy with strangers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 18.1-24.9 kg (male), 15.9-22.7 kg (female) | United Kingdom (Wales) |
CB257 | Wire-Haired Fox Terrier | Alert, quick of movement, keen of expression, on tiptoe of expectation at slightest provocation. Friendly, forthcoming and fearless. | 39 cm | 8.25 kg | United Kingdom (England) |
CB269 | Standard Poodle | Intelligent and quick-to-please | 56-66 cm |
2020 |
VanBuren,S.L.,Minor,K.M.,Grahn,R.A.,Mickelson,J.R.,Grahn,J.C.,Malvick,J.,Colangelo,J.R.,Mueller,E.,Kuehnlein,P.,Kehl,A.: :
A Third <i>MLPH</i> Variant Causing Coat Color Dilution in Dogs. Genes (Basel) 11:, 2020. Pubmed reference: 32531980 . DOI: 10.3390/genes11060639 . |
2018 |
Bauer,A.,Kehl,A.,Jagannathan,V.,Leeb,T.: :
A novel MLPH variant in dogs with coat colour dilution. Anim Genet 49:94-97, 2018. Pubmed reference: 29349785 . DOI: 10.1111/age.12632 . |
2009 |
Perego,R.,Proverbio,D.,Roccabianca,P.,Spada,E.: :
Color dilution alopecia in a blue Doberman pinscher crossbreed. Can Vet J 50:511-4, 2009. Pubmed reference: 19436637 . |
2009 |
Welle,M.,Philipp,U.,Rüfenacht,S.,Roosje,P.,Scharfenstein,M.,Schuetz,E.,Brenig,B.,Linek,M.,Mecklenburg,L.,Grest,P.,Drögemüller,M.,Haase,B.,Leeb,T.,Drögemüller,C.: :
MLPH genotype melanin phenotype correlation in dilute dogs. Journal of Heredity 100:S75–S79, 2009. |
2007 |
Drögemüller,C.,Philipp,U.,Haase,B.,Günzel-Apel,A.R.,Leeb,T.: :
A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007. Pubmed reference: 17519392 . DOI: 10.1093/jhered/esm021 . |
2005 |
Kim,JH.,Kang,KI.,Sohn,HJ.,Woo,GH.,Jean,YH.,Hwang,EK.: :
Color-dilution alopecia in dogs. J Vet Sci 6:259-61, 2005. Pubmed reference: 16131833 . |
2005 |
Philipp,U.,Hamann,H.,Mecklenburg,L.,Nishino,S.,Mignot,E.,Gunzel-Apel,AR.,Schmutz,SM.,Leeb,T.: :
Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs. BMC Genet 6:34, 2005. Pubmed reference: 15960853 . DOI: 10.1186/1471-2156-6-34 . |
2005 |
Philipp,U.,Quignon,P.,Scott,A.,Andre,C.,Breen,M.,Leeb,T.: :
Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers. J Hered 96:774-6, 2005. Pubmed reference: 15958794 . DOI: 10.1093/jhered/esi079 . |
2002 |
Laffort-Dassot,C.,Beco,L.,Carlotti,D.N.: :
Follicular dysplasia in five Weimaraners Veterinary Dermatology 13:253-260, 2002. Pubmed reference: 12358609 . |
1999 |
Castellano,M.C.,Idiart,J.R.: :
Colour dilution alopecia in a German Shepherd dog Canine Practice 24:6-7, 1999. |
1998 |
Rothstein,E.,Scott,D.W.,Miller,W.H.,Bagladi,M.S.: :
A retrospective study of dysplastic hair follicles and abnormal melanization in dogs with follicular dysplasia syndromes or endocrine skin disease Veterinary Dermatology 9:235-241, 1998. |
1997 |
Madewell,B.R.,Ihrke,P.J.,Griffey,S.M.: :
Multiple skin tumours in a Doberman Pinscher with colour dilution alopecia Veterinary Dermatology 8:59-61, 1997. |
1996 |
Beco,L.,Fontaine,J.,Gross,T.L.,Charlier,G.: :
Colour dilution alopecia in seven Dachshunds - a clinical study and the hereditary, microscopical and ultrastructural aspect of the disease Veterinary Dermatology 7:91-97, 1996. |
1995 |
Lowenstein,C.: :
Color mutant alopecia in a yorkshire terrier [German] Kleintierpraxis 40:781 ff., 1995. |
1995 |
Roperto,F.,Cerundolo,R.,Restucci,B.,Vincensi,M.R.,Decaprariis,D.,Devico,G.,Maiolino,P.: :
Colour dilution alopecia (cda) in ten yorkshire terriers Veterinary Dermatology 6:171-178, 1995. |
1993 |
Finnie,J.W.,Tham,V.L.: :
Colour Mutant Alopecia in a Kelpie X Border Collie Dog Australian Veterinary Journal 70:388-389, 1993. Pubmed reference: 8257319 . |