The detail information of Color mutant alopecia
Basic Information

Another Name: Blue Doberman Syndrome

Disease Description: A condition where certain colored areas of a dog's skin grows less or no fur. Commonly seen in Yorkshire terriers, blue Doberman pinschers and fawn Irish setters.

Inherit Mode: -

Disease Symptom: Affected dogs are born with a healthy hair coat. At 6 months of age or later, the coat becomes thin, brittle, and dry and takes on a moth-eaten appearance. The skin becomes rough and scaly. Blackheads, pimples, and pustules (puss filled pimples) appear on the involved areas.

Disease Cause: The coat mutation has a genetic basis.

Disease Diagnose: Diagnosis is made by physical exam.

Treat Method: Treatment is directed toward relieving the surface condition, which involves shampoos that rehydrate the skin, remove scales, and flush the hair follicles. These must be prescribed by your vet. Because the affected hair is fragile and comes out easily, vigorous brushing and the use of harsh or inappropriate shampoos aggravates the problem and should be avoided.

Breeder Advice: Affected dogs should not be bred.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Coat colour, dilution, MLPH-related Colour mutant alopecia; Color dilution alopecia; Colour dilution alopecia Autosomal Recessive MLPH
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB76 Cirneco dell'Etna Affectionate, Friendly, Independent 18-19.5 inches (male), 16.5-18 inches (female) 22-26 pounds (male), 17-22 pounds (female) Italy
CB89 Dogo Argentino Loyal, trustworthy,courageous 61-68.6 cm (male), 59.7-66 cm (female) 36.3-45.4 kg Argentina
CB97 English Springer Spaniel Friendly, playful, obedient at home; hardworking and steady in the field 50.8 cm (male), 48.3 cm (female) 22.7 kg (male), 18.1 kg (female) United Kingdom (England)
CB120 Great Pyrenees Calm, patient, smart; strong-willed yet affectionate 68.6-81.3 cm (male), 63.5-73.7 cm (female) 45.4 kg & up (male), 38.6 kg & up (female) France, Spain
CB132 Irish Terrier Bold, dashing, even reckless; stouthearted at work, tenderhearted at home 45.7 cm 12.2 kg (male), 11.3 kg (female) Ireland
CB136 German Jagdterrier Courageous, Intelligent, Hardworking 33-40cm 7.7-9.9kg Germany
CB253 Welsh Springer Spaniel Happy, upbeat, family oriented; reserved but not shy with strangers 45.7-48.3 cm (male), 43.2-45.7 cm (female) 18.1-24.9 kg (male), 15.9-22.7 kg (female) United Kingdom (Wales)
CB257 Wire-Haired Fox Terrier Alert, quick of movement, keen of expression, on tiptoe of expectation at slightest provocation. Friendly, forthcoming and fearless. 39 cm 8.25 kg United Kingdom (England)
CB269 Standard Poodle Intelligent and quick-to-please 56-66 cm
References
2020 VanBuren,S.L.,Minor,K.M.,Grahn,R.A.,Mickelson,J.R.,Grahn,J.C.,Malvick,J.,Colangelo,J.R.,Mueller,E.,Kuehnlein,P.,Kehl,A.: :
A Third <i>MLPH</i> Variant Causing Coat Color Dilution in Dogs. Genes (Basel) 11:, 2020.
Pubmed reference: 32531980 . DOI: 10.3390/genes11060639 .
2018 Bauer,A.,Kehl,A.,Jagannathan,V.,Leeb,T.: :
A novel MLPH variant in dogs with coat colour dilution. Anim Genet 49:94-97, 2018.
Pubmed reference: 29349785 . DOI: 10.1111/age.12632 .
2009 Perego,R.,Proverbio,D.,Roccabianca,P.,Spada,E.: :
Color dilution alopecia in a blue Doberman pinscher crossbreed. Can Vet J 50:511-4, 2009.
Pubmed reference: 19436637 .
2009 Welle,M.,Philipp,U.,Rüfenacht,S.,Roosje,P.,Scharfenstein,M.,Schuetz,E.,Brenig,B.,Linek,M.,Mecklenburg,L.,Grest,P.,Drögemüller,M.,Haase,B.,Leeb,T.,Drögemüller,C.: :
MLPH genotype melanin phenotype correlation in dilute dogs. Journal of Heredity 100:S75–S79, 2009.
2007 Drögemüller,C.,Philipp,U.,Haase,B.,Günzel-Apel,A.R.,Leeb,T.: :
A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007.
Pubmed reference: 17519392 . DOI: 10.1093/jhered/esm021 .
2005 Kim,JH.,Kang,KI.,Sohn,HJ.,Woo,GH.,Jean,YH.,Hwang,EK.: :
Color-dilution alopecia in dogs. J Vet Sci 6:259-61, 2005.
Pubmed reference: 16131833 .
2005 Philipp,U.,Hamann,H.,Mecklenburg,L.,Nishino,S.,Mignot,E.,Gunzel-Apel,AR.,Schmutz,SM.,Leeb,T.: :
Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs. BMC Genet 6:34, 2005.
Pubmed reference: 15960853 . DOI: 10.1186/1471-2156-6-34 .
2005 Philipp,U.,Quignon,P.,Scott,A.,Andre,C.,Breen,M.,Leeb,T.: :
Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers. J Hered 96:774-6, 2005.
Pubmed reference: 15958794 . DOI: 10.1093/jhered/esi079 .
2002 Laffort-Dassot,C.,Beco,L.,Carlotti,D.N.: :
Follicular dysplasia in five Weimaraners Veterinary Dermatology 13:253-260, 2002.
Pubmed reference: 12358609 .
1999 Castellano,M.C.,Idiart,J.R.: :
Colour dilution alopecia in a German Shepherd dog Canine Practice 24:6-7, 1999.
1998 Rothstein,E.,Scott,D.W.,Miller,W.H.,Bagladi,M.S.: :
A retrospective study of dysplastic hair follicles and abnormal melanization in dogs with follicular dysplasia syndromes or endocrine skin disease Veterinary Dermatology 9:235-241, 1998.
1997 Madewell,B.R.,Ihrke,P.J.,Griffey,S.M.: :
Multiple skin tumours in a Doberman Pinscher with colour dilution alopecia Veterinary Dermatology 8:59-61, 1997.
1996 Beco,L.,Fontaine,J.,Gross,T.L.,Charlier,G.: :
Colour dilution alopecia in seven Dachshunds - a clinical study and the hereditary, microscopical and ultrastructural aspect of the disease Veterinary Dermatology 7:91-97, 1996.
1995 Lowenstein,C.: :
Color mutant alopecia in a yorkshire terrier [German] Kleintierpraxis 40:781 ff., 1995.
1995 Roperto,F.,Cerundolo,R.,Restucci,B.,Vincensi,M.R.,Decaprariis,D.,Devico,G.,Maiolino,P.: :
Colour dilution alopecia (cda) in ten yorkshire terriers Veterinary Dermatology 6:171-178, 1995.
1993 Finnie,J.W.,Tham,V.L.: :
Colour Mutant Alopecia in a Kelpie X Border Collie Dog Australian Veterinary Journal 70:388-389, 1993.
Pubmed reference: 8257319 .