The detail information of Cushing's disease (hyperadrenocorticism)
Basic Information
Another Name: hyperadrenocorticism
Disease Description: A disease characterized by an excess secretion of cortisosteroids from the adrenal glands.
Inherit Mode: -
Disease Symptom: The condition mostly affects middle-aged and older dogs, and the warning signs may be harder to spot in the beginning.You might notice your dog:Is thirstier than usual;Seems hungrier;Pees more often; housebroken dogs may have indoor accidents.;Loses hair or it seems slow to grow;Gets a pot belly;Has thinning skin;Seems very tired and inactive;Pants a lot;Gets skin infections
Disease Cause: -
Disease Diagnose: There’s no method that’s 100% accurate for diagnosing Cushing's. So the vet will do a few tests to see what may be causing your pet's symptoms and to rule out other health problems.Your vet will start by testing your dog’s blood and his pee. These exams can detect diluted urine, urinary tract infections, or problems with a protein mostly found in the liver and bones called alkaline phosphatase. All of these are common in animals with Cushing’s. If the results show signs of the condition, your vet will follow up with hormone screening tests, such as:ACTH stimulation test ;Low dose dexamethasone suppression (LDDS) test .If it seems like your pup could have Cushing’s, your vet might want to do an ultrasound scan of his belly. This imaging test will help her see if there’s a tumor on the adrenal glands. That could affect the kind of treatment he needs.
Treat Method: If Cushing’s syndrome comes from a tumor on your pet’s adrenal glands, the vet might be able to remove it with surgery, which will cure him of the problem.Usually, a dog can live an active, normal life with medication to treat the condition, though he’ll need it for the rest of his life. Drugs are best for dogs with Cushing’s syndrome caused by the pituitary gland or for those with a tumor on their adrenal gland that can't be removed with surgery.
Breeder Advice: -
Disease Description Source: Link
Associated Diseases
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Cushing disease, pituitary-dependent hyperadrenocorticism | - | - | - | ||
| Hyperadrenocorticism, generic | - | - | - | ||
| ACTH-independent adrenal Cushing syndrome, somatic | - | - | GNAS |
Associated Breeds
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB4 | Akita | Dignified, courageous, and profoundly loyal to their humans | 66-71.1 cm (male), 61-66 cm (female) | 45.4-59 kg (male), 31.8-45.4 kg (female) | Japan |
| CB47 | Bouvier des Flandres(Flanders Cattle Dog) | Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders | 62.2-69.9 cm (male), 59.7-67.3 cm (female) | 31.8-49.9 kg | Belgium |
| CB142 | Irish Blue Terrier | Smart and alert; people oriented, with a dash of Irish humor in his heart | 45.7-49.5 cm (male), 44.5-48.3 cm (female) | 15-18.1 kg (male), females weigh slightly less than males | Ireland |
| CB256 | English Whippet | Calm, affectionate, and playful | 48.3-55.9 cm (male), 45.7-53.3 cm (female) | 11.3-18.1 kg | England |
| CB263 | Akbash Dog | Calm, quiet, and steady.,independent ,loyal, gentle, and quietly affectionate with its own family, including children and family pets, but remains aloof and suspicious toward strangers. | 76.2-86.4 cm (male), 71.1-81.3 cm (female) | 54.4 kg (male), 40.8 kg (female) | Turkey |
References
| 2019 |
Bennaim,M.,Shiel,R.E.,Mooney,C.T.: :
Diagnosis of spontaneous hyperadrenocorticism in dogs. Part 1: Pathophysiology, aetiology, clinical and clinicopathological features. Vet J 252:105342, 2019. Pubmed reference: 31554593 . DOI: 10.1016/j.tvjl.2019.105342 . |
| 2017 |
De-Marco,V.,Carvalho,L.R.,Guzzo,M.F.,Oliveira,P.S.L.,Gomes,L.G.,Mendonca,B.B.: :
An activating mutation in the CRHR1 gene is rarely associated with pituitary-dependent hyperadrenocorticism in poodles. Clinics (Sao Paulo) 72:575-581, 2017. Pubmed reference: 29069262 . DOI: 10.6061/clinics/2017(09)09 . |
| 2016 |
Nolte,A.,Strube,C.,Raue,K.,Brämer,C.,Baumgärtner,W.,Wohlsein,P.: :
[Subcutaneous Taenia crassiceps-cysticercosis in a dog with Cushing's syndrome]. Tierarztl Prax Ausg K Kleintiere Heimtiere 44:53-8, 2016. Pubmed reference: 26763526 . DOI: 10.15654/TPK-150145 . |
| 2016 |
DelMagno,S.,Grinwis,G.C.,Voorhout,G.,Meij,B.P.: :
Dynamic computed tomography of the pituitary gland using a single slice scanner in dogs with pituitary-dependent hypercortisolism. Res Vet Sci 107:42-9, 2016. Pubmed reference: 27473973 . DOI: 10.1016/j.rvsc.2016.04.005 . |
| 2016 |
Nagata,N.,Kojima,K.,Yuki,M.: :
Comparison of survival times for dogs with pituitary-dependent hyperadrenocorticism in a primary-care hospital: Treated with trilostane versus untreated. J Vet Intern Med :, 2016. Pubmed reference: 27906457 . DOI: 10.1111/jvim.14617 . |
| 2016 |
Noh,S.,Kim,H.S.,Chang,J.,Kang,J.H.,Chang,D.,Yang,M.P.: :
Serum cholecystokinin concentrations in dogs with naturally acquired pituitary-dependent hyperadrenocorticism. Am J Vet Res 77:1101-7, 2016. Pubmed reference: 27668581 . DOI: 10.2460/ajvr.77.10.1101 . |
| 2016 |
Sato,A.,Teshima,T.,Ishino,H.,Harada,Y.,Yogo,T.,Kanno,N.,Hasegawa,D.,Hara,Y.: :
A magnetic resonance imaging-based classification system for indication of trans-sphenoidal hypophysectomy in canine pituitary-dependent hypercortisolism. J Small Anim Pract 57:240-6, 2016. Pubmed reference: 27101315 . DOI: 10.1111/jsap.12474 . |
| 2016 |
Teshima,T.,Matsumoto,H.,Okusa,T.,Uchiyama,R.,Koyama,H.: :
Carbenoxolone disodium treatment for canine pituitary-dependent hyperadrenocorticism. PLoS One 11:e0166267, 2016. Pubmed reference: 27824928 . DOI: 10.1371/journal.pone.0166267 . |
| 2015 |
Takano,H.,Kokubu,A.,Sugimoto,K.,Sunahara,H.,Aoki,T.,Fijii,Y.: :
Left ventricular structural and functional abnormalities in dogs with hyperadrenocorticism. J Vet Cardiol 17:173-81, 2015. Pubmed reference: 26319177 . DOI: 10.1016/j.jvc.2015.07.002 . |
| 2015 |
Tvarijonaviciute,A.,Caldin,M.,Martinez-Subiela,S.,Tecles,F.,Pastor,J.,Ceron,J.J.: :
Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism. Vet J 203:262-3, 2015. Pubmed reference: 25555340 . DOI: 10.1016/j.tvjl.2014.12.002 . |
| 2014 |
Chen,H.Y.,Lien,Y.H.,Huang,H.P.: :
Assessment of left ventricular function by two-dimensional speckle-tracking echocardiography in small breed dogs with hyperadrenocorticism. Acta Vet Scand 56:88, 2014. Pubmed reference: 25551792 . DOI: 10.1186/s13028-014-0088-5 . |
| 2013 |
Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 . |
| 2013 |
Kol,A.,Nelson,R.W.,Gosselin,R.C.,Borjesson,D.L.: :
Characterization of thrombelastography over time in dogs with hyperadrenocorticism. Vet J :, 2013. Pubmed reference: 23838206 . DOI: 10.1016/j.tvjl.2013.05.047 . |
| 2013 |
Kool,M.M.,Galac,S.,Spandauw,C.G.,Kooistra,H.S.,Mol,J.A.: :
Activating mutations of GNAS in canine cortisol-secreting adrenocortical tumors. J Vet Intern Med 27:1486-92, 2013. Pubmed reference: 24112376 . DOI: 10.1111/jvim.12194 . |
| 2011 |
Gilor,C.,Graves,TK.: :
Interpretation of Laboratory Tests for Canine Cushing's Syndrome. Top Companion Anim Med 26:98-108, 2011. Pubmed reference: 21596349 . DOI: 10.1053/j.tcam.2011.03.001 . |
| 2007 |
Brown,CG.,Graves,TK.: :
Hyperadrenocorticism: treating dogs. Compend Contin Educ Vet 29:132-4, 136, 138 passim; quiz 144-5, 2007. Pubmed reference: 17726933 . |
| 2007 |
Peterson,ME.: :
Diagnosis of hyperadrenocorticism in dogs. Clin Tech Small Anim Pract 22:2-11, 2007. Pubmed reference: 17542191 . DOI: 10.1053/j.ctsap.2007.02.007 . |
| 2005 |
Granger,N.,deFornel,P.,Devauchelle,P.,Segond,S.,Delisle,F.,Rosenberg,D.: :
Plasma pro-opiomelanocortin, pro-adrenocorticotropin hormone, and pituitary adenoma size in dogs with Cushing's disease. J Vet Intern Med 19:23-8, 2005. Pubmed reference: 15715043 . |
| 2005 |
Barker,EN.,Campbell,S.,Tebb,AJ.,Neiger,R.,Herrtage,ME.,Reid,SW.,Ramsey,IK.: :
A comparison of the survival times of dogs treated with mitotane or trilostane for pituitary-dependent hyperadrenocorticism. J Vet Intern Med 19:810-5, 2005. Pubmed reference: 16355673 . |
| 2005 |
Behrend,EN.,Kemppainen,RJ.,Boozer,AL.,Whitley,EM.,Smith,AN.,Busch,KA.: :
Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism. J Am Vet Med Assoc 227:1762-7, 2005. Pubmed reference: 16342524 . |
| 2005 |
Benitah,N.,Feldman,EC.,Kass,PH.,Nelson,RW.: :
Evaluation of serum 17-hydroxyprogesterone concentration after administration of ACTH in dogs with hyperadrenocorticism. J Am Vet Med Assoc 227:1095-101, 2005. Pubmed reference: 16220669 . |
| 2005 |
Hanson,JM.,van't,HM.,Voorhout,G.,Teske,E.,Kooistra,HS.,Meij,BP.: :
Efficacy of transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med 19:687-94, 2005. Pubmed reference: 16231713 . |
| 2005 |
Hill,KE.,Scott-Moncrieff,JC.,Koshko,MA.,Glickman,LT.,Glickman,NW.,Nelson,RW.,Blevins,WE.,Oliver,JW.: :
Secretion of sex hormones in dogs with adrenal dysfunction. J Am Vet Med Assoc 226:556-61, 2005. Pubmed reference: 15742696 . |
| 2005 |
Martínez,N.I.,Panciera,D.L.,Abbott,J.A.,Ward,D.L.: :
Evaluation of pressor sensitivity to norepinephrine infusion in dogs with iatrogenic hyperadrenocorticism. Pressor sensitivity in dogs with hyperadrenocorticism. Res Vet Sci 78:25-31, 2005. Pubmed reference: 15500836 . DOI: 10.1016/j.rvsc.2004.05.004 . |
| 2004 |
Bryden,SL.,Burrows,AK.,O'hara,AJ.: :
Mycobacterium goodii infection in a dog with concurrent hyperadrenocorticism. Vet Dermatol 15:331-8, 2004. Pubmed reference: 15500486 . DOI: 10.1111/j.1365-3164.2004.00383.x . |
| 2004 |
Wenger,M.,Sieber-Ruckstuhl,N.S.,Müller,C.,Reusch,C.E.: :
Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticism. Am J Vet Res 65:1245-50, 2004. Pubmed reference: 15478772 . |
| 2003 |
Hess,R.S.,Kass,P.H.,Van,Winkle,T.J.: :
Association between diabetes mellitus, hypothyroidism or hyperadrenocorticism, and atherosclerosis in dogs Journal of Veterinary Internal Medicine 17:489-94, 2003. Pubmed reference: 12892299 . |
| 2003 |
Lee,W.M.,Meij,B.P.,Bhatti,S.F.,Mol,J.A.,Rijnberk,A.,Kooistra,H.S.: :
Pulsatile secretion pattern of growth hormone in dogs with pituitary-dependent hyperadrenocorticism Domestic Animal Endocrinology 24:59-68, 2003. Pubmed reference: 12450625 . |
| 2002 |
Alenza,M.D.P.,Guerrero,B.,Melian,C.,Ynaraja,E.,Pena,L.: :
Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog Journal of Small Animal Practice 43:104-108, 2002. Pubmed reference: 11924551 . |
| 2002 |
Behrend,E.N.,Kemppainen,R.J.,Clark,T.P.,Salman,M.D.,Peterson,M.E.: :
Diagnosis of hyperadrenocorticism in dogs: a survey of internists and dermatologists Journal of the American Veterinary Medical Association 220:1643-1649, 2002. Pubmed reference: 12051503 . |
| 2002 |
Bhatti,S.F.M.,DeVliegher,S.P.,VanHam,L.,Kooistra,H.S.: :
Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism Molecular & Cellular Endocrinology 197:97-103, 2002. |
| 2002 |
Bosje,J.T.,Rijnberk,A.,Mol,J.A.,Voorhout,G.,Kooistra,H.S.: :
Plasma concentrations of ACTH precursors correlate with pituitary size and resistance to dexamethasone in dogs with pituitary-dependent hyperadrenocorticism Domestic Animal Endocrinology 22:201-210, 2002. Pubmed reference: 12044610 . |
| 2002 |
Goy-Thollot,I.,Pechereau,D.,Keroack,S.,Dezempte,J.C.,Bonnet,J.M.: :
Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs Journal of Small Animal Practice 43:489-492, 2002. Pubmed reference: 12463264 . |
| 2002 |
Laus,J.L.,dos,Santos,C.,Talieri,I.C.,Oria,A.P.,Bechara,G.H.: :
Combined corneal lipid and calcium degeneration in a dog with hyperadrenocorticism: a case report Veterinary Ophthalmology 5:61-64, 2002. Pubmed reference: 11940251 . |
| 2002 |
Meij,B.,Voorhout,G.,Rijnberk,A.: :
Progress in transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in dogs and cats Molecular & Cellular Endocrinology 197:89-96, 2002. |
| 2002 |
Neiger,R.,Ramsey,I.,O'Connor,J.,Hurley,K.J.,Mooney,C.T.: :
Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism Veterinary Record 150:799-804, 2002. Pubmed reference: 12120922 . |
| 2002 |
Ristic,J.M.E.,Ramsey,I.K.,Heath,F.M.,Evans,H.J.,Herrtage,M.E.: :
The use of 17-hydroxyprogesterone in the diagnosis of canine hyperadrenocorticism Journal of Veterinary Internal Medicine 16:433-439, 2002. Pubmed reference: 12141305 . |
| 2002 |
Schoemaker,N.J.,Mol,J.A.,Lumeij,J.T.,Rijnberk,A.: :
I plasma concentrations of adrenocorticotrophic hormone and alpha-melanocyte-stimulating hormone in ferrets (Mustela putorius furo) with hyperadrenocorticism American Journal of Veterinary Research 63:1395-9, 2002. Pubmed reference: 12371766 . |
| 2002 |
vanderVlugt-Meijer,R.H.,Voorhout,G.,Meij,B.P.: :
Imaging of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism Molecular & Cellular Endocrinology 197:81-87, 2002. |
| 2001 |
Meij,B.P.: :
Hypophysectomy as a treatment for canine and feline Cushing's disease Veterinary Clinics of North America - Small Animal Practice 31:1015-+, 2001. |
| 2001 |
Peterson,M.E.: :
Medical treatment of canine pituitary dependent hyperadrenocorticism (Cushing's disease) Veterinary Clinics of North America - Small Animal Practice 31:1005-+, 2001. |
| 2001 |
Reusch,C.: :
Modern diagnosis and treatment of canine Cushing syndrome Magyar Allatorvosok Lapja 123:222-224, 2001. |
| 2001 |
Reusch,C.,Glaus,T.,Wess,G.,Tomsa,K.,Horauf,A.,Stankeova,S.,Geissbuhler,U.,Kaser-Hotz,B.: :
Clinical, routine laboratory and specific endocrine investigations in dogs with pituitary-dependent Cushing's syndrome: A comparison between dogs with macro- and dogs with microtumors. Kleintierpraxis 46:261-+, 2001. |
| 2001 |
Reusch,C.,Stankeova,S.,Geissbuhler,U.,Glaus,T.,Tomsa,K.,Horauf,A.,Kaser-Hotz,B.: :
Correlation between pituitary size measured by computed tomography and neurological symptoms in dogs with Cushing's syndrome Kleintierpraxis 46:133-+, 2001. |
| 2001 |
Behrend,E.N.,Kemppainen,R.J.: :
Diagnosis of canine hyperadrenocorticism Veterinary Clinics of North America - Small Animal Practice 31:985-+, 2001. |
| 2001 |
Nett,C.S.,Reusch,C.E.: :
Mitotane (Lysodren((R))) intolerance - alternative treatment options in dogs with pituitary dependent hyperadrenocorticism - a case report Kleintierpraxis 46:725-+, 2001. |
| 2000 |
Ottenjann,M.,Munster,M.: :
Mitotane monotherapy of canine Cushing's syndrome: Evaluation of a short initial therapy protocol on 20 outpatient patients [German] Kleintierpraxis 45:511-+, 2000. |
| 2000 |
Berry,C.R.,Hawkins,E.C.,Hurley,K.J.,Monce,K.: :
Frequency of pulmonary mineralization and hypoxemia in 21 dogs with pituitary-dependent hyperadrenocorticism Journal of Veterinary Internal Medicine 14:151-156, 2000. Pubmed reference: 10772486 . |
| 2000 |
Bruyette,D.S.: :
Diagnosing hyperadrenocorticism in a hyperactive dog Veterinary Medicine 95:438, 2000. |
| 2000 |
Bruyette,D.S.: :
Treating canine hyperadrenocorticism of unknown etiology Veterinary Medicine 95:828-829, 2000. |
| 2000 |
Schwarz,T.,Stork,C.K.,Mellor,D.,Sullivan,M.: :
Osteopenia and other radiographic signs in canine hyperadrenocorticism Journal of Small Animal Practice 41:491-495, 2000. Pubmed reference: 11105787 . |
| 2000 |
Zerbe,C.A.: :
Differentiating tests to evaluate hyperadrenocorticism in dogs and cats Compendium on Continuing Education for the Practicing Veterinarian 22:149-+, 2000. |
| 2000 |
Zerbe,C.A.: :
Screening tests to diagnose hyperadrenocorticism in cats and dogs Compendium on Continuing Education for the Practicing Veterinarian 22:17-+, 2000. |
| 1999 |
Behrend,E.N.,Kemppainen,R.J.,Clark,T.P.,Salman,M.D.,Peterson,M.E.: :
Treatment of hyperadrenocorticism in dogs: a survey of internists and dermatologists Journal of the American Veterinary Medical Association 215:938-943, 1999. Pubmed reference: 10511856 . |
| 1999 |
Forrester,S.D.,Troy,G.C.,Dalton,M.N.,Huffman,J.W.,Holtzman,G.: :
Retrospective evaluation of urinary tract infection in 42 dogs with hyperadrenocorticism or diabetes mellitus or both Journal of Veterinary Internal Medicine 13:557-560, 1999. Pubmed reference: 10587255 . |
| 1999 |
Gould,S.M.,Baines,E.A.,Mannion,P.A.,Evans,H.,Herrtage,M.E.: :
Use of endogenous ACTH concentration and adrenal ultrasonography to distinguish the cause of canine hyperadrenocorticism Journal of Small Animal Practice 42:113-121, 1999. |
| 1999 |
Greco,D.S.,Peterson,M.E.,Davidson,A.P.,Feldman,E.C.,Komurek,K.: :
Concurrent pituitary and adrenal tumors in dogs with hyperadrenocorticism: 17 cases (1978-1995) Journal of the American Veterinary Medical Association 214:1349-1353, 1999. Pubmed reference: 10319177 . |
| 1999 |
Harris,P.: :
Primary hypoadrenocorticism in a dog receiving glucocorticoid supplementation Canadian Veterinary Journal - Revue Veterinaire Canadienne 40:129-131, 1999. |
| 1999 |
Horauf,A.,Reusch,C.: :
Effect of mitotane therapy on adrenal gland size in dogs with pituitary dependent hyperadrenocorticism - an ultrasonographic study [German] Schweizer Archiv fur Tierheilkunde 141:239-245, 1999. Pubmed reference: 10354742 . |
| 1999 |
Huang,H.P.,Yang,H.L.,Liang,S.L.,Lien,Y.H.,Chen,K.Y.: :
Latrogenic hyperadrenocorticism in 28 Dogs Journal of the American Animal Hospital Association 35:200-207, 1999. Pubmed reference: 10333257 . |
| 1999 |
Kerl,M.E.,Peterson,M.E.,Wallace,M.S.,Melian,C.,Kemppainen,R.J.: :
Evaluation of a low-dose synthetic adrenocorticotropic hormone stimulation test in clinically normal dogs and dogs with naturally developing hyperadrenocorticism Journal of the American Veterinary Medical Association 214:1497-1501, 1999. Pubmed reference: 10340075 . |
| 1999 |
Melian,C.,Stefanacci,J.,Peterson,M.E.,Kintzer,P.P.: :
Radiographic findings in dogs with naturally-occurring primary hypoadrenocorticism Journal of the American Animal Hospital Association 35:208-212, 1999. Pubmed reference: 10333258 . |
| 1999 |
Norman,E.J.,Thompson,H.,Mooney,C.T.: :
Dynamic adrenal function testing in eight dogs with hyperadrenocorticism associated with adrenocortical neoplasia Veterinary Record 144:551-554, 1999. Pubmed reference: 10371012 . |
| 1999 |
Peterson,M.E.: :
Medical treatment of pituitary-dependent hyperadrenocorticism in dogs: Should L-deprenyl (Anipryl) ever be used? Journal of Veterinary Internal Medicine 13:289-290, 1999. Pubmed reference: 10449217 . |
| 1999 |
Reusch,C.E.,Steffen,T.,Hoerauf,A.: :
The efficacy of L-Deprenyl in dogs with pituitary-dependent hyperadrenocorticism Journal of Veterinary Internal Medicine 13:291-301, 1999. Pubmed reference: 10449218 . |
| 1999 |
Zerbe,C.A.: :
The hypothalamic-pituitary-adrenal axis and pathophysiology of hyperadrenocorticism Compendium on Continuing Education for the Practicing Veterinarian 21:1134-+, 1999. |
| 1999 |
den,Hertog,E.,Braakman,J.C.A.,Teske,E.,Kooistra,H.S.,Rijnberk,A.: :
Results of non-selective adrenocorticolysis by o,p '-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism Veterinary Record 144:12-17, 1999. Pubmed reference: 10028568 . |
| 1998 |
Barry,P.: :
Hyperadrenocorticism (HAC) in the dog - cushings-syndrome Irish Veterinary Journal 51:489-490, 1998. |
| 1998 |
Behrend,E.N.,Kemppainen,R.J.: :
Medical therapy of canine cushings-syndrome Compendium on Continuing Education for the Practicing Veterinarian 20:679 ff., 1998. |
| 1998 |
Gfeller,G.,Reusch,C.: :
Case report from small animal practice [German] Schweizer Archiv fur Tierheilkunde 140:375-379, 1998. Pubmed reference: 9757786 . |
| 1998 |
Meij,B.P.: :
Transsphenoid hypophysectomy for treating dogs with Cushings-disease [Dutch] Tijdschrift voor Diergeneeskunde 123:530-534, 1998. Pubmed reference: 9764462 . |
| 1998 |
Anon.: :
Evaluation of urine protein content in dogs with pituitary-dependent hyperadrenocorticism (vol 212, pg 369, 1998) Journal of the American Veterinary Medical Association 213:644, 1998. |
| 1998 |
Bennett,P.F.,Norman,E.J.: :
Mitotane (o,p'-ddd) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma Australian Veterinary Journal 76:101-103, 1998. Pubmed reference: 9578778 . |
| 1998 |
Goossens,M.M.C.,Feldman,E.C.,Theon,A.P.,Koblik,P.D.: :
Efficacy of cobalt 60 radiotherapy in dogs with pituitary-dependent hyperadrenocorticism Journal of the American Veterinary Medical Association 212:374 ff., 1998. |
| 1998 |
Hess,R.S.,Ward,C.R.: :
Concurrent canine hyperadrenocorticism and diabetes mellitus - diagnosis and treatment Compendium on Continuing Education for the Practicing Veterinarian 20:701 ff., 1998. |
| 1998 |
Hess,R.S.,Ward,C.R.: :
Diabetes mellitus, hyperadrenocorticism, and hypothyroidism in a dog Journal of the American Animal Hospital Association 34:204-207, 1998. Pubmed reference: 9590447 . |
| 1998 |
Hurley,K.J.,Vaden,S.L.: :
Evaluation of urine protein content in dogs with pituitary-dependent hyperadrenocorticism Journal of the American Veterinary Medical Association 212:369 ff., 1998. |
| 1998 |
Meij,B.P.,Voorhout,G.,Vandeningh,T.S.G.A.M.,Hazewinkel,H.A.W.,Teske,E.,Rijnberk,A.: :
Results of transsphenoidal hypophysectomy in 52 dogs with pituitary-dependent hyperadrenocorticism Veterinary Surgery 27:246-261, 1998. Pubmed reference: 9605236 . |
| 1998 |
Randolph,J.F.,Toomey,J.,Center,S.A.,Scarlett,J.M.,Reimers,T.,Graham,P.,Nachreiner,R.F.: :
Use of the urine cortisol-to-creatinine ratio for monitoring dogs with pituitary-dependent hyperadrenocorticism during induction treatment with mitotane (o,p'-ddd) American Journal of Veterinary Research 59:258-261, 1998. Pubmed reference: 9522940 . |
| 1998 |
Rubin,S.I.,Toolan,L.,Halperin,M.L.: :
Trimethoprim-induced exacerbation of hyperkalemia in a dog with hypoadrenocorticism Journal of Veterinary Internal Medicine 12:186-188, 1998. Pubmed reference: 9595382 . |
| 1998 |
Swinney,G.B.,Foster,S.F.,Church,D.B.,Malik,R.: :
Myotonia associated with hyperadrenocorticism in two dogs Australian Veterinary Journal 76:722-724, 1998. Pubmed reference: 9862060 . |
| 1998 |
Thuroczy,J.,Balogh,L.,Huszenicza,G.,Janoki,G.A.,Kulcsar,M.: :
Diagnosis of hyperadrenocorticism in dogs as compared to human diagnostic methods - a review Acta Veterinaria Hungarica 46:157-173, 1998. Pubmed reference: 9704520 . |
| 1997 |
Yamini,B.,Vandenbrink,P.L.,Refsal,K.R.: :
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (cushings disease) in a dog Veterinary Pathology 34:57-60, 1997. Pubmed reference: 9150550 . |
| 1997 |
Angles,J.M.,Feldman,E.C.,Nelson,R.W.,Feldman,M.S.: :
Use of urine cortisol-creatinine ratio versus adrenocorticotropic hormone stimulation testing for monitoring mitotane treatment of pituitary-dependent hyperadrenocorticism in dogs Journal of the American Veterinary Medical Association 211:1002 ff., 1997. |
| 1997 |
Bruyette,D.S.,Ruehl,W.W.,Entriken,T.L.,Darling,L.A.,Griffin,D.W.: :
Treating canine pituitary-dependent hyperadrenocorticism with l-deprenyl Veterinary Medicine 92:710 ff., 1997. |
| 1997 |
Bruyette,D.S.,Ruehl,W.W.,Entriken,T.,Griffin,D.,Darling,L.: :
Management of canine pituitary-dependent hyperadrenocorticism with 1-deprenyl (anipryl) Veterinary Clinics of North America - Small Animal Practice 27:273 ff., 1997. |
| 1997 |
Denhertog,E.,Braakman,J.C.A.,Teske,E.,Kooistra,H.S.,Rijnberk,A.: :
Treatment of pituitary-dependent hyperadrenocorticism in the dog by non-selective adrenocorticolysis with o,p'-ddd Veterinary Quarterly 19:S 17, 1997. |
| 1997 |
Galac,S.,Kooistra,H.S.,Teske,E.,Rijnberk,A.: :
Urinary corticoid/creatinine ratios in the differentiation between pituitary-dependent hyperadrenocorticism and hyperadrenocorticism due to adrenocortical tumour in the dog Veterinary Quarterly 19:17-20, 1997. Pubmed reference: 9225424 . |
| 1997 |
Guptill,L.,Scottmoncrieff,J.C.,Bottoms,G.,Glickman,L.,Johnson,M.,Glickman,N.,Nelson,R.,Bertoy,E.: :
Use of the urine cortisol/creatinine ratio to monitor treatment response in dogs with pituitary-dependent hyperadrenocorticism Journal of the American Veterinary Medical Association 210:1158 ff., 1997. |
| 1997 |
Guptill,L.,Scottmoncrieff,J.C.,Widmer,W.R.: :
Diagnosis of canine hyperadrenocorticism Veterinary Clinics of North America - Small Animal Practice 27:215 ff., 1997. |
| 1997 |
Jensen,A.L.,Iversen,L.,Koch,J.,Hoier,R.,Petersen,T.K.: :
Evaluation of the urinary cortisol - creatinine ratio in the diagnosis of hyperadrenocorticism in dogs Journal of Small Animal Practice 38:99-102, 1997. Pubmed reference: 9097240 . |
| 1997 |
Kooistra,H.S.,Voorhout,G.,Mol,J.A.,Rijnberk,A.: :
Correlation between impairment of glucocorticoid feedback and the size of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism Journal of Endocrinology 152:387-394, 1997. Pubmed reference: 9071959 . |
| 1997 |
Mackay,B.M.: :
Hyperadrenocorticism in the dog [Review] Australian Veterinary Practitioner 27:147 ff., 1997. |
| 1997 |
Meij,B.P.,Mol,J.A.,Bevers,M.M.,Rijnberk,A.: :
Alterations in anterior pituitary function of dogs with pituitary-dependent hyperadrenocorticism Journal of Endocrinology 154:505-512, 1997. Pubmed reference: 9379128 . |
| 1997 |
Meij,B.P.,Mol,J.A.,Bevers,M.M.,Rijnberk,A.: :
Residual pituitary function after transsphenoidal hypophysectomy in dogs with pituitary-dependent hyperadrenocorticism Journal of Endocrinology 155:531-539, 1997. Pubmed reference: 9487998 . |
| 1997 |
Miyamoto,T.,Horie,T.,Ogawa,Y.,Baba,E.,Kuwamura,M.: :
Hyperadrenocorticism with severe calcinosis cutis in a dog Canine Practice 22:24 ff., 1997. |
| 1997 |
Nichols,R.: :
Complications and concurrent disease associated with canine hyperadrenocorticism Veterinary Clinics of North America - Small Animal Practice 27:309 ff., 1997. |
| 1997 |
Peterson,M.E.,Kintzer,P.P.: :
Medical treatment of pituitary-dependent hyperadrenocorticism - mitotane Veterinary Clinics of North America - Small Animal Practice 27:255 ff., 1997. |
| 1997 |
Vanwijk,P.A.M.,Croughs,R.J.M.,Rijnberk,A.,Mol,J.A.: :
In vivo and in vitro characteristics of corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism Veterinary Quarterly 19:S 10-S 11, 1997. |
| 1997 |
Vanwijk,P.A.,Rijnberk,A.,Croughs,R.J.M.,Meij,B.P.,Vanleeuwen,I.S.,Sprang,E.P.M.,Mol,J.A.: :
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism Journal of Endocrinological Investigation 20:1-7, 1997. Pubmed reference: 9075064 . |
| 1996 |
Thuroczy,J.,Huszenicza,G.,Magdus,M.,Hargittai,T.,Papp,L.,Voros,K.,Rudas,P.: :
On the canine cushings syndrome - survey 1 - pathophysiology and symptoms of the hyperadrenocorticism - survey 2 - diagnosis and therapy of the hyperadrenocorticism [Hungarian] Magyar Allatorvosok Lapja 51:42 ff., 1996. |
| 1996 |
Bertoy,E.H.,Feldman,E.C.,Nelson,R.W.,Dublin,A.B.,Reid,M.H.,Feldman,M.S.: :
One-year follow-up evaluation of magnetic resonance imaging of the brain in dogs with pituitary-dependent hyperadrenocorticism Journal of the American Veterinary Medical Association 208:1268 ff., 1996. |
| 1996 |
Galac,S.,Kooistra,H.S.: :
Urinary corticoid/creatinine ratio in dogs with hyperadrenocorticism Veterinary Quarterly 18:S 35, 1996. |
| 1996 |
Grooters,A.M.,Biller,D.S.,Theisen,S.K.,Miyabayashi,T.: :
Ultrasonographic characteristics of the adrenal glands in dogs with pituitary-dependent hyperadrenocorticism - comparison with normal dogs Journal of Veterinary Internal Medicine 10:110-115, 1996. Pubmed reference: 8743208 . |
| 1996 |
Montgomery,T.M.,Nelson,R.W.,Feldman,E.C.,Robertson,K.,Polonsky,K.S.: :
Basal and glucagon-stimulated plasma c-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism Journal of Veterinary Internal Medicine 10:116-122, 1996. Pubmed reference: 8743209 . |
| 1996 |
Nelson,R.W.: :
Diagnosis and medical treatment of pituitary-dependent hyperadrenocorticism Veterinary Quarterly 18:S 26-S 27, 1996. |
| 1996 |
Ortega,T.M.,Feldman,E.C.,Nelson,R.W.,Willits,N.,Cowgill,L.D.: :
Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism Journal of the American Veterinary Medical Association 209:1724-1729, 1996. Pubmed reference: 8921029 . |
| 1996 |
Soffner,C.,Reusch,C.: :
Assessment of urinary cortisol/creatinine ratio in the diagnosis of hyperadrenocorticism in dogs [German] Kleintierpraxis 41:85 ff., 1996. |
| 1995 |
Regnier,A.,Garnier,F.: :
Growth hormone responses to growth hormone-releasing hormone and clonidine in dogs with Cushing's syndrome Research in Veterinary Science 58:169-173, 1995. Pubmed reference: 7761697 . |
| 1995 |
Bertoy,E.H.,Feldman,E.C.,Nelson,R.W.,Duesberg,C.A.,Kass,P.H.,Reid,M.H.,Dublin,A.B.: :
Magnetic resonance Imaging of the brain in dogs with recently diagnosed but untreated pituitary-dependent hyperadrenocorticism Journal of the American Veterinary Medical Association 206:651-656, 1995. Pubmed reference: 7744686 . |
| 1995 |
Horauf,A.,Reusch,C.: :
Visualisation of the suprarenal glands by means of ultrasound: Examinations in healthy dogs, in dogs with non-endocrine diseases as well as in dogs with hyperadrenocorticism Kleintierpraxis 40:351, 1995. |
| 1995 |
Kaplan,A.J.,Peterson,M.E.: :
Effects of desoxycorticosterone pivalate administration on blood pressure in dogs with primary hypoadrenocorticism Journal of the American Veterinary Medical Association 206:327-331, 1995. Pubmed reference: 7751240 . |
| 1995 |
Thiessen,A.E.,Cowell,R.L.,Clinkenbeard,K.D.,Meinkoth,J.H.,Sherrell,S.: :
Hypoadrenocorticism in a puppy Canine Practice 20:18-22, 1995. |
| 1995 |
Vondehn,B.J.,Nelson,R.W.,Feldman,E.C.,Griffey,S.M.: :
Pheochromocytoma and hyperadrenocorticism in dogs: Six cases (1982-1992) Journal of the American Veterinary Medical Association 207:322-324, 1995. Pubmed reference: 7628933 . |
| 1995 |
Whitley,N.T.: :
Megaoesophagus and glucocorticoid-deficient hypoadrenocorticism in a dog Journal of Small Animal Practice 36:132-135, 1995. Pubmed reference: 7783439 . |
| 1995 |
Widmer,W.R.,Guptill,L.: :
Clinical update - Imaging techniques for facilitating diagnosis of hyperadrenocorticism in dogs and cats Journal of the American Veterinary Medical Association 206:1857-1864, 1995. Pubmed reference: 7790297 . |
| 1994 |
Berry,C.R.,Ackerman,N.,Monce,K.: :
Pulmonary Mineralization in Four Dogs with Cushings Syndrome Veterinary Radiology & Ultrasound 35:10-16, 1994. |
| 1994 |
Feldman,E.C.,Nelson,R.W.: :
Comparative aspects of Cushing's syndrome in dogs and cats Endocrinology and Metabolism Clinics of North America 23:671-691, 1994. Pubmed reference: 7805662 . |
| 1994 |
Vanwijk,P.A.,Rijnberk,A.,Croughs,R.J.M.,Wolfswinkel,J.,Selman,P.J.,Mol,J.A.: :
Responsiveness to Corticotropin-Releasing Hormone and Vasopressin in Canine Cushings Syndrome European Journal of Endocrinology 130:410-416, 1994. Pubmed reference: 8162173 . |
| 1994 |
Mack,R.E.: :
Screening Tests Used in the Diagnosis of Canine Hyperadenocorticism Seminars in Veterinary Medicine and Surgery - Small Animal 9:118-122, 1994. Pubmed reference: 7938929 . |
| 1994 |
Mack,R.E.,Wilson,S.M.,Feldman,E.C.: :
Diagnosis of Hyperadrenocorticism in Dogs Compendium on Continuing Education for the Practicing Veterinarian 16:311, 1994. |
| 1994 |
Nichols,R.: :
Concurrent Illness and Complications Associated with Canine Hyperadrenocorticism Seminars in Veterinary Medicine and Surgery - Small Animal 9:132-136, 1994. Pubmed reference: 7938932 . |
| 1994 |
Peterson,M.E.,Kintzer,P.P.: :
Medical Treatment of Pituitary-Dependent Hyperadrenocorticism in Dogs Seminars in Veterinary Medicine and Surgery - Small Animal 9:127-131, 1994. Pubmed reference: 7938931 . |
| 1994 |
Stewart,L.J.: :
The Integumentary Changes of Hyperadrenocorticism Seminars in Veterinary Medicine and Surgery - Small Animal 9:123-126, 1994. Pubmed reference: 7938930 . |
| 1993 |
Barrie,J.,Watson,T.D.G.,Stear,M.J.,Nash,A.S.: :
Plasma Cholesterol and Lipoprotein Concentrations in the Dog - The Effects of Age, Breed, Gender and Endocrine Disease Journal of Small Animal Practice 34:507-512, 1993. |
| 1993 |
Cayzer,J.,Jones,B.R.: :
Canine Hyperadrenocorticism New Zealand Veterinary Journal 41:53-68, 1993. |
| 1993 |
Janssens,L.A.A.,Janssens,D.L.: :
Successful Long Term Ketoconazole Treatment of Hyperadrenocorticism in a Dog Vlaams Diergeneeskundig Tijdschrift 62:186-188, 1993. |
| 1993 |
Kemppainen,R.J.,Peterson,M.E.: :
Circulating Concentration of Dexamethasone in Healthy Dogs, Dogs with Hyperadrenocorticism, and Dogs with Nonadrenal Illness During Dexamethasone Suppression Testing American Journal of Veterinary Research 54:1765-1769, 1993. Pubmed reference: 8250405 . |
| 1993 |
Smiley,L.E.,Peterson,M.E.: :
Evaluation of a Urine Cortisol - Creatinine Ratio as a Screening Test for Hyperadrenocorticism in Dogs Journal of Veterinary Internal Medicine 7:163-168, 1993. Pubmed reference: 8331610 . |
| 1992 |
Scholten-Sloof,BE.,Knol,BW.,Rijnberk,A.,Mol,JA.,Middleton,DJ.,Ubbink,GJ.: :
Pituitary-dependent hyperadrenocorticism in a family of Dandie Dinmont terriers. J Endocrinol 135:535-42, 1992. Pubmed reference: 1487706 . |
| 1992 |
Scholten-Sloof,BE.,Knol,BW.,Rijnberk,A.,Mol,JA.,Middleton,DJ.,Ubbink,GJ.: :
Pituitary-dependent hyperadrenocorticism in a family of Dandie Dinmont terriers. J Endocrinol 135:535-42, 1992. Pubmed reference: 1487706 . |
| 1992 |
vanSluijs,F.J.,Sjollema,B.E.: :
Adrenalectomy in 36 dogs and 2 cats with hyperadrenocorticism. Tijdschr Diergeneeskd :29S, 1992. Pubmed reference: 1585317 . |
| 1991 |
Wolfsheimer,K.J.,Peterson,M.E.: :
Erythrocyte Insulin Receptors in Dogs with Spontaneous Hyperadrenocorticism American Journal of Veterinary Research 52:917-921, 1991. Pubmed reference: 1883096 . |
| 1990 |
Blaxter,A.C.,Gruffydd-Jones,T.J.: :
Concurrent Diabetes Mellitus and Hyperadrenocorticism in the Dog - Diagnosis and Management of 8 Cases Journal of Small Animal Practice 31:117-122, 1990. |
| 1990 |
Mauldin,G.N.,Burk,R.L.: :
The use of diagnostic computerized tomography and radiation therapy in canine and feline hyperadrenocorticism. Probl Vet Med 2:557-64, 1990. Pubmed reference: 2134074 . |