Another Name: gray collie syndrome
Disease Description: A condition characterized by periodic lowering of neutrophils, a type of white blood cell. Commonly seen in grey collies.
Inherit Mode: In Collies the disease is associated with silver/gray gene and occurs in autosomal-recessive form.
Disease Symptom: Affected dogs bear a striking gray coat, which is different from the normal sable or tricolor coat, and have eye defects such as microphthalmia and scleral ectasia. The light-colored nose is a characteristic and diagnostic feature.Puppies are stunted and weak and less active at birth than their normal litter mates. The term 'cyclic' means the appearance of neutropenia alternating with normal neutrophil count. Beginning within 12 days after birth, the pups show marked sign of cyclic neutropenia associated with infections (diarrhea, conjunctivitis, gingivitis, or arthritis) at 11- to 14-day intervals.
Disease Cause: -
Disease Diagnose: -
Treat Method: Recent advances in stem cell transplantation showed a thrapeutic potential of allogeneic DLA-identical Hematopoietic Cell Transplantation (HCT) has been investigated for a wide range of canine non-malignant hematological and non-hematological disorders, such as congenital immunological and enzymatic deficiencies, and Duchenne muscular dystrophy. Allogeneic marrow grafts from dog leukocyte antigen (DLA)-identical littermates corrected cyclic neutropenia.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Neutropenia, cyclic | Grey Collie Syndrome; Gray Collie Syndrome | Autosomal Recessive | AP3B1 |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB78 | Cocker Spaniel | Happy, smart, gentle | 36.8-39.4 cm (male), 34.3-36.8 cm (female) | 11.3-13.6 kg (male), 9.1-11.3 kg (female) | |
| CB80 | Coton de Tulear | Bright, happy-go-lucky, endlessly charming; born to love and to be loved | 25.4-27.9 cm (male), 22.9-25.4 cm (female) | 4.1-6.8 kg (male), 3.6-5.9 kg (female) | Madagascar |
| CB188 | Poodle | Proud, active and very smart | 25.4 cm & under (toy), 25.4-38.1 cm (miniature), over 38.1 cm (standard) | 1.8-2.7 kg (toy), 4.5-6.8 kg (miniature), 27.2-31.8 kg (male standard), 18.1-22.7 kg (female standard) | Germany, France |
| 2010 |
Meng,R.,Bridgman,R.,Toivio-Kinnucan,M.,Niemeyer,GP.,Vernau,W.,Hock,T.,Lothrop,CD.: :
Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010. Pubmed reference: 19941936 . DOI: 10.1016/j.exphem.2009.09.010 . |
| 2008 |
Pacheco,J.M.,Traulsen,A.,Antal,T.,Dingli,D.: :
Cyclic neutropenia in mammals. Am J Hematol 83:920-1, 2008. Pubmed reference: 18951469 . DOI: 10.1002/ajh.21295 . |
| 2004 |
Benson,KF.,Person,RE.,Li,FQ.,Williams,K.,Horwitz,M.: :
Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia. Nucleic Acids Res 32:6327-33, 2004. Pubmed reference: 15576359 . DOI: 10.1093/nar/gkh974 . |
| 2004 |
Horwitz,M.,Benson,KF.,Duan,Z.,Li,FQ.,Person,RE.: :
Hereditary neutropenia: dogs explain human neutrophil elastase mutations. Trends Mol Med 10:163-70, 2004. Pubmed reference: 15059607 . DOI: 10.1016/j.molmed.2004.02.002 . |
| 2003 |
Benson,K.F.,Li,F.Q.,Person,R.E.,Albani,D.,Duan,Z.,Wechsler,J.,Meade-White,K.,Williams,K.,Acland,G.M.,Niemeyer,G.,Lothrop,C.D.,Horwitz,M.: :
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase Nature Genetics 35:90-6, 2003. Pubmed reference: 12897784 . DOI: 10.1038/ng1224 . |
| 2003 |
Yanay,O.,Barry,S.C.,Katen,L.J.,Brzezinski,M.,Flint,L.Y.,Christensen,J.,Liggitt,D.,Dale,D.C.,Osborne,W.R.: :
Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery Blood 102:2046-52, 2003. Pubmed reference: 12750178 . DOI: 10.1182/blood-2002-12-3722 . |
| 1996 |
Allen,W.M.,Pocock,P.I.,Dalton,P.M.,Richards,H.E.,Aitken,M.M.: :
Cyclic neutropenia in Collies Veterinary Record 138:371-372, 1996. Pubmed reference: 8737267 . |
| 1995 |
Brabb,T.,Maggioprice,L.,Dale,D.,Deeb,B.,Liggitt,D.: :
Pancreatic adenocarcinoma in two grey collie dogs with cyclic hematopoiesis Laboratory Animal Science 45:357-362, 1995. Pubmed reference: 7474871 . |
| 1991 |
Lothrop,C.D.,Candler,R.V.,Pratt,H.L.,Urso,I.M.,Jones,J.B.,Carroll,R.C.: :
Characterization of Platelet Function in Cyclic Hematopoietic Dogs Experimental Hematology 19:916-922, 1991. Pubmed reference: 1893969 . |
| 1978 |
Dunn,C.D.R.,Jones,J.B.,Jolly,J.D.,Lange,R.D.: :
Cell proliferation of canine cyclic hematopoietic marrow in diffusion chambers Proceedings of the Society for Experimental Biology and Medicine 158:50-53, 1978. Pubmed reference: 351627 . |
| 1978 |
Yang,T.J.: :
Recovery of hair coat colour in Gray Collie (cyclic neutropenia) normal bone marrow transplant chimeras American Journal of Pathology 91:149-153, 1978. Pubmed reference: 347941 . |
| 1975 |
Cheville,N.F.: :
The Grey Collie syndrome (cyclic neutropenia) Journal of the American Animal Hospital Association 11:350-352, 1975. |
| 1974 |
Adamson,J.W.,Dale,D.C.,Elm,R.J.: :
Regulation of cyclic erthropoiesis in the Grey Collie Journal of Clinical Investigation 52:1A abstract, 1974. |
| 1974 |
Adamson,J.W.,Dale,D.C.,Elm,R.J.: :
Hematopoiesis in the Grey Collie dog : studies of the regulation of erythropoiesis Journal of Clinical Investigation 54:965-973, 1974. Pubmed reference: 4430726 . DOI: 10.1172/JCI107837 . |
| 1973 |
Patt,H.M.,Lund,J.E.,Maloney,M.A.: :
Cyclic hematopoiesis in grey Collie dogs: a stem cell problem Blood 42:873-884, 1973. Pubmed reference: 4796766 . |
| 1972 |
Dale,D.C.,Alling,D.W.,Wolff,S.M.: :
Cyclic hematopoiesis: the mechanism of cyclic neutropenia in Grey Collie dogs Journal of Clinical Investigation 51:2197-2204, 1972. Pubmed reference: 5054472 . DOI: 10.1172/JCI107027 . |
| 1971 |
Reynold,H.Y.,Dale,D.C.,Wolff,S.M.,Johnson,J.S.: :
Serum immunoglobulin levels in Grey Collies Society for Experimental Biology and Medicine 136:574-577, 1971. |
| 1970 |
Lund,J.E.,Padgett,G.A.,Gorham,J.R.: :
Additional evidence on the inheritance of cyclic neutropenia in the dog Journal of Heredity 61:47-49, 1970. Pubmed reference: 5529685 . |
| 1967 |
Lund,J.E.,Padgett,G.A.,Ott,R.L.: :
Cyclic neutropenia in Grey Collie dogs Blood 29:452-461, 1967. Pubmed reference: 6067150 . |