The detail information of Thrombocytopenia
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2008

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB60 Cairn Terrier 25.4 cm (male), 24.1 cm (female) 6.4 kg (male), 5.9 kg (female) United Kingdom (Scotland)
CB67 Cavalier King Charles Spaniel 30.5-33 cm 5.9-8.2 kg United Kingdom (England)
CB167 Norfolk Terrier 22.9-25.4 cm 5-5.4 kg United Kingdom
Associated Gene
Symbol Description Species Position Other Links
TUBB1 tubulin, beta 1 class VI Canis lupus familiaris Chr24 : 44625242 - 44634669 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Cooper,S.A.,Huang,A.A.,Raskin,R.E.,Weng,H.Y.,Scott-Moncrieff,J.C.: :
Clinical data, clinicopathologic findings and outcome in dogs with amegakaryocytic thrombocytopenia and primary immune-mediated thrombocytopenia. J Small Anim Pract 57:142-7, 2016.
Pubmed reference: 26799165 . DOI: 10.1111/jsap.12441 .
2014 Gelain,M.E.,Bertazzolo,W.,Tutino,G.,Pogliani,E.,Cian,F.,Boudreaux,M.K.: :
A novel point mutation in the β1-tubulin gene in asymptomatic macrothrombocytopenic Norfolk and Cairn Terriers. Vet Clin Pathol 43:317-21, 2014.
Pubmed reference: 25060661 . DOI: 10.1111/vcp.12168 .
2014 Schwartz,D.,Sharkey,L.,Armstrong,P.J.,Knudson,C.,Kelley,J.: :
Platelet Volume and Plateletcrit in Dogs with Presumed Primary Immune-Mediated Thrombocytopenia. J Vet Intern Med :, 2014.
Pubmed reference: 25056453 . DOI: 10.1111/jvim.12405 .
2014 Zmigrodzka,M.,Guzera,M.,Winnicka,A.: :
Evaluation of reticulated platelets in dogs with breed-related thrombocytopenia. Pol J Vet Sci 17:137-42, 2014.
Pubmed reference: 24724481 .
2013 Collicutt,N.B.,Garner,B.: :
Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate. Vet Clin Pathol :, 2013.
Pubmed reference: 24138476 . DOI: 10.1111/vcp.12089 .
2011 Bodié,K.,Gagne,G.D.,Sramek,M.K.,Desmond,D.J.,Abel,S.J.,Fagerland,J.A.: :
Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: a case report. Toxicol Pathol 39:980-7, 2011.
Pubmed reference: 21859886 . DOI: 10.1177/0192623311416261 .
2010 Gelain,M.E.,Tutino,G.F.,Pogliani,E.,Bertazzolo,W.: :
Macrothrombocytopenia in a group of related Norfolk terriers. Vet Rec 167:493-4, 2010.
Pubmed reference: 20871084 . DOI: 10.1136/vr.c4782 .
2009 Botsch,V.,Küchenhoff,H.,Hartmann,K.,Hirschberger,J.: :
Retrospective study of 871 dogs with thrombocytopenia. Vet Rec 164:647-51, 2009.
Pubmed reference: 19465753 .
2009 Shelah-Goraly,M.,Aroch,I.,Kass,P.H.,Bruchim,Y.,Ofri,R.: :
A prospective study of the association of anemia and thrombocytopenia with ocular lesions in dogs. Vet J 182:187-92, 2009.
Pubmed reference: 18664411 . DOI: 10.1016/j.tvjl.2008.05.027 .
2008 Bommer,N.X.,Shaw,D.J.,Milne,E.M.,Ridyard,A.E.: :
Platelet distribution width and mean platelet volume in the interpretation of thrombocytopenia in dogs. J Small Anim Pract 49:518-24, 2008.
Pubmed reference: 18793252 . DOI: 10.1111/j.1748-5827.2008.00636.x .
2008 Davis,B.,Toivio-Kinnucan,M.,Schuller,S.,Boudreaux,MK.: :
Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J Vet Intern Med 22:540-5, 2008.
Pubmed reference: 18466252 . DOI: 10.1111/j.1939-1676.2008.0085.x .
2008 Putsche,J.C.,Kohn,B.: :
Primary immune-mediated thrombocytopenia in 30 dogs (1997-2003). J Am Anim Hosp Assoc 44:250-7, 2008.
Pubmed reference: 18762561 . DOI: 10.5326/0440250 .
2005 Middleton,SM.: :
Immune-mediated thrombocytopenia in a 4-month-old German shepherd dog. Can Vet J 46:443-5, 2005.
Pubmed reference: 16018567 .
2005 Singh,MK.,Lamb,WA.: :
Idiopathic thrombocytopenia in Cavalier King Charles Spaniels. Aust Vet J 83:700-3, 2005.
Pubmed reference: 16315671 .
2004 Cowan,SM.,Bartges,JW.,Gompf,RE.,Hayes,JR.,Moyers,TD.,Snider,CC.,Gerard,DA.,Craft,RM.,Muenchen,RA.,Carroll,RC.: :
Giant platelet disorder in the Cavalier King Charles Spaniel. Exp Hematol 32:344-50, 2004.
Pubmed reference: 15050744 . DOI: 10.1016/j.exphem.2004.01.008 .
2004 Olsen,L.H.,Kristensen,A.T.,Qvortrup,K.,Pedersen,H.D.: :
Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia. J Vet Diagn Invest 16:167-70, 2004.
Pubmed reference: 15053372 .
2002 Pedersen,H.D.,Haggstrom,J.,Olsen,L.H.,Christensen,K.,Selin,A.,Burmeister,M.L.,Larsen,H.: :
Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait Journal of Veterinary Internal Medicine 16:169-173, 2002.
Pubmed reference: 11899033 .
2002 Rozanski,E.A.,Callan,M.B.,Hughes,D.,Sanders,N.,Giger,U.: :
Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs Journal of the American Veterinary Medical Association 220:477-481, 2002.
Pubmed reference: 11860242 .
2000 LeGrange,S.N.,Fossum,T.W.,Lemire,T.,Storts,R.W.,Thomas,J.S.: :
Thrombosis of the caudal vena cava presenting as an unusual cause of an abdominal mass and thrombocytopenia in a dog Journal of the American Animal Hospital Association 36:143-151, 2000.
Pubmed reference: 10730625 .
1998 Mischke,R.,Adamik,A.: :
Sensitivity of resonance thrombography in thrombocytopenia in dogs [German] Berliner und Munchener Tierarztliche Wochenschrift 111:302-305, 1998.
Pubmed reference: 9741188 .
1997 Smedile,L.E.,Houston,D.M.,Taylor,S.M.,Post,K.,Searcy,G.P.: :
Idiopathic, asymptomatic thrombocytopenia in cavalier king charles spaniels - 11 cases (1983-1993) Journal of the American Animal Hospital Association 33:411-415, 1997.
Pubmed reference: 9278116 .
1995 Mackin,A.: :
Canine immune-mediated thrombocytopenia .3. Compendium on Continuing Education for the Practicing Veterinarian 17:515, 1995.
1995 Mackin,A.: :
Canine immune-mediated thrombocytopenia .1. Compendium on Continuing Education for the Practicing Veterinarian 17:353, 1995.
1994 Eksell,P.,Haggstrom,J.,Kvart,C.,Karlsson,A.: :
Thrombocytopenia in the Cavalier King Charles Spaniel Journal of Small Animal Practice 35:153-155, 1994.
1994 Kristensen,A.T.,Weiss,D.J.,Klausner,J.S.,Laber,J.,Christie,D.J.: :
Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of having immune-mediated thrombocytopenia American Journal of Veterinary Research 55:1111-1114, 1994.
Pubmed reference: 7978651 .