The detail information of Glaucoma, primary open angle, ADAMTS10-related
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2011

Species-specific name: Primary open angle glaucoma

Species-specific symbol: POAG

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB24 English Beagle 33 cm & under 33-38.1 cm under 9.1 kg (5.9 inches & under), 9.1-13.6 kg (5.9-6.8 inches) United Kingdom (England)
CB170 Norwegian Elkhound 52.1 cm (male), 49.5 cm (female) 24.9 kg (male), 21.8 kg (female) Norway
CB217 Japanese Shiba Inu 35.6-43.2 cm (male), 33-40.6 cm (female) 8.2-10.9 kg (male), 6.8-9.1 kg (female) Japan
CB218 Shih Tzu(Chrysanthemum Dog) 20.3-27.9 cm 4.1-7.3 kg China
Associated Gene
Symbol Description Species Position Other Links
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 Canis lupus familiaris Chr20 : 53638525 - 53618496 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017.
Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 .
2016 Boote,C.,Palko,J.R.,Sorensen,T.,Mohammadvali,A.,Elsheikh,A.,Komáromy,A.M.,Pan,X.,Liu,J.: :
Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Mol Vis 22:503-17, 2016.
Pubmed reference: 27212875 .
2016 Palko,J.R.,Morris,H.J.,Pan,X.,Harman,C.D.,Koehl,K.L.,Gelatt,K.N.,Plummer,C.E.,Komáromy,A.M.,Liu,J.: :
Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. PLoS One 11:e0156466, 2016.
Pubmed reference: 27271467 . DOI: 10.1371/journal.pone.0156466 .
2015 Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015.
Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 .
2015 Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015.
Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 .
2014 Ahonen,S.J.,Kaukonen,M.,Nussdorfer,F.D.,Harman,C.D.,Komáromy,A.M.,Lohi,H.: :
A novel missense mutation in ADAMTS10 in Norwegian Elkhound primary glaucoma. PLoS One 9:e111941, 2014.
Pubmed reference: 25372548 . DOI: 10.1371/journal.pone.0111941 .
2013 Kuchtey,J.,Kunkel,J.,Esson,D.,Sapienza,J.S.,Ward,D.A.,Plummer,C.E.,Gelatt,K.N.,Kuchtey,R.W.: :
Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in Beagles. Invest Ophthalmol Vis Sci 54:1881-6, 2013.
Pubmed reference: 23422823 . DOI: 10.1167/iovs.12-10796 .
2013 Palko,J.R.,Iwabe,S.,Pan,X.,Agarwal,G.,Komáromy,A.M.,Liu,J.: :
Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation. Invest Ophthalmol Vis Sci 54:2685-95, 2013.
Pubmed reference: 23518772 . DOI: 10.1167/iovs.12-10621 .
2012 Kato,K.,Sasaki,N.,Shastry,B.S.: :
Retinal ganglion cell (RGC) death in glaucomatous Beagles is not associated with mutations in p53 and NTF4 genes. Vet Ophthalmol 15 Suppl 2:8-12, 2012.
Pubmed reference: 22524196 . DOI: 10.1111/j.1463-5224.2012.01024.x .
2011 Kuchtey,J.,Olson,L.M.,Rinkoski,T.,Mackay,E.O.,Iverson,T.M.,Gelatt,K.N.,Haines,J.L.,Kuchtey,R.W.: :
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306, 2011.
Pubmed reference: 21379321 . DOI: 10.1371/journal.pgen.1001306 .
2009 Kato,K.,Kamida,A.,Sasaki,N.,Shastry,BS.: :
Evaluation of the CYP1B1 gene as a candidate gene in Beagles with primary open-angle glaucoma (POAG). Mol Vis 15:2470-4, 2009.
Pubmed reference: 1428571 .
2008 Mackay,E.O.,Källberg,M.E.,Gelatt,K.N.: :
Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles. Vet Ophthalmol 11:177-85, 2008.
Pubmed reference: 18435660 . DOI: 10.1111/j.1463-5224.2008.00617.x .
1995 Brooks,D.E.,Strubbe,D.T.,Kubilis,P.S.,Mackay,E.O.,Samuelson,D.A.,Gelatt,K.N.: :
Histomorphometry of the optic nerves of normal dogs and dogs with hereditary glaucoma Experimental Eye Research 60:71-89, 1995.
Pubmed reference: 7720807 .
1981 Gelatt,K.N.,Gum,G.G.: :
Inheritance of primary glaucoma in the Beagle. Am J Vet Res 42:1691-3, 1981.
Pubmed reference: 7325430 .
1980 Peiffer,R.L.,Gum,G.G.,Grimson,R.C.,Gelatt,K.N.: :
Aqueous humor outflow in Beagles with inherited glaucoma: constant pressure perfusion. Am J Vet Res 41:1808-13, 1980.
Pubmed reference: 7212410 .
1977 Gelatt,K.N.,Peiffer,R.L.,Gwin,R.M.,Gum,G.G.,Williams,L.W.: :
Clinical manifestations of inherited glaucoma in the beagle. Invest Ophthalmol Vis Sci 16:1135-42, 1977.
Pubmed reference: 924743 .
1972 Gelatt,K.N.: :
Familial glaucoma in the Beagle dog Journal of the American Animal Hospital Association 8:23-28, 1972.