Possible human homologues (MIM numbers):
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Recessive
Considered a defect: yes
Year key mutation first reported: 2011
Species-specific name: Primary open angle glaucoma
Species-specific symbol: POAG
More detail information can see in
iDog Breed Number | Breed Name | Personality | Height | Weight | History | Breed Source |
---|---|---|---|---|---|---|
CB24 | English Beagle | 33 cm & under 33-38.1 cm | under 9.1 kg (5.9 inches & under), 9.1-13.6 kg (5.9-6.8 inches) | United Kingdom (England) | ||
CB170 | Norwegian Elkhound | 52.1 cm (male), 49.5 cm (female) | 24.9 kg (male), 21.8 kg (female) | Norway | ||
CB217 | Japanese Shiba Inu | 35.6-43.2 cm (male), 33-40.6 cm (female) | 8.2-10.9 kg (male), 6.8-9.1 kg (female) | Japan | ||
CB218 | Shih Tzu(Chrysanthemum Dog) | 20.3-27.9 cm | 4.1-7.3 kg | China |
Symbol | Description | Species | Position | Other Links |
---|---|---|---|---|
ADAMTS10 | ADAM metallopeptidase with thrombospondin type 1 motif, 10 | Canis lupus familiaris | Chr20 : 53638525 - 53618496 | Homologene, Ensembl, NCBI gene |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2016 |
Boote,C.,Palko,J.R.,Sorensen,T.,Mohammadvali,A.,Elsheikh,A.,Komáromy,A.M.,Pan,X.,Liu,J.: :
Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Mol Vis 22:503-17, 2016. Pubmed reference: 27212875 . |
2016 |
Palko,J.R.,Morris,H.J.,Pan,X.,Harman,C.D.,Koehl,K.L.,Gelatt,K.N.,Plummer,C.E.,Komáromy,A.M.,Liu,J.: :
Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. PLoS One 11:e0156466, 2016. Pubmed reference: 27271467 . DOI: 10.1371/journal.pone.0156466 . |
2015 |
Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 . |
2015 |
Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 . |
2014 |
Ahonen,S.J.,Kaukonen,M.,Nussdorfer,F.D.,Harman,C.D.,Komáromy,A.M.,Lohi,H.: :
A novel missense mutation in ADAMTS10 in Norwegian Elkhound primary glaucoma. PLoS One 9:e111941, 2014. Pubmed reference: 25372548 . DOI: 10.1371/journal.pone.0111941 . |
2013 |
Kuchtey,J.,Kunkel,J.,Esson,D.,Sapienza,J.S.,Ward,D.A.,Plummer,C.E.,Gelatt,K.N.,Kuchtey,R.W.: :
Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in Beagles. Invest Ophthalmol Vis Sci 54:1881-6, 2013. Pubmed reference: 23422823 . DOI: 10.1167/iovs.12-10796 . |
2013 |
Palko,J.R.,Iwabe,S.,Pan,X.,Agarwal,G.,Komáromy,A.M.,Liu,J.: :
Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation. Invest Ophthalmol Vis Sci 54:2685-95, 2013. Pubmed reference: 23518772 . DOI: 10.1167/iovs.12-10621 . |
2012 |
Kato,K.,Sasaki,N.,Shastry,B.S.: :
Retinal ganglion cell (RGC) death in glaucomatous Beagles is not associated with mutations in p53 and NTF4 genes. Vet Ophthalmol 15 Suppl 2:8-12, 2012. Pubmed reference: 22524196 . DOI: 10.1111/j.1463-5224.2012.01024.x . |
2011 |
Kuchtey,J.,Olson,L.M.,Rinkoski,T.,Mackay,E.O.,Iverson,T.M.,Gelatt,K.N.,Haines,J.L.,Kuchtey,R.W.: :
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306, 2011. Pubmed reference: 21379321 . DOI: 10.1371/journal.pgen.1001306 . |
2009 |
Kato,K.,Kamida,A.,Sasaki,N.,Shastry,BS.: :
Evaluation of the CYP1B1 gene as a candidate gene in Beagles with primary open-angle glaucoma (POAG). Mol Vis 15:2470-4, 2009. Pubmed reference: 1428571 . |
2008 |
Mackay,E.O.,Källberg,M.E.,Gelatt,K.N.: :
Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles. Vet Ophthalmol 11:177-85, 2008. Pubmed reference: 18435660 . DOI: 10.1111/j.1463-5224.2008.00617.x . |
1995 |
Brooks,D.E.,Strubbe,D.T.,Kubilis,P.S.,Mackay,E.O.,Samuelson,D.A.,Gelatt,K.N.: :
Histomorphometry of the optic nerves of normal dogs and dogs with hereditary glaucoma Experimental Eye Research 60:71-89, 1995. Pubmed reference: 7720807 . |
1981 |
Gelatt,K.N.,Gum,G.G.: :
Inheritance of primary glaucoma in the Beagle. Am J Vet Res 42:1691-3, 1981. Pubmed reference: 7325430 . |
1980 |
Peiffer,R.L.,Gum,G.G.,Grimson,R.C.,Gelatt,K.N.: :
Aqueous humor outflow in Beagles with inherited glaucoma: constant pressure perfusion. Am J Vet Res 41:1808-13, 1980. Pubmed reference: 7212410 . |
1977 |
Gelatt,K.N.,Peiffer,R.L.,Gwin,R.M.,Gum,G.G.,Williams,L.W.: :
Clinical manifestations of inherited glaucoma in the beagle. Invest Ophthalmol Vis Sci 16:1135-42, 1977. Pubmed reference: 924743 . |
1972 |
Gelatt,K.N.: :
Familial glaucoma in the Beagle dog Journal of the American Animal Hospital Association 8:23-28, 1972. |