The detail information of Glaucoma, primary open angle, ADAMTS17-related
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2015

Species-specific name: -

Species-specific symbol: POAG

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB21 Basset Fauve de Bretagne(Fawn Brittany Basset) 32–38 cm (13–15 in) France
CB22 Basset Hound up to 38.1 cm 18.1-29.5 kg France
Associated Gene
Symbol Description Species Position Other Links
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 Canis lupus familiaris Chr3 : 41014731 - 41340884 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Jeanes,E.C.,Oliver,J.A.C.,Ricketts,S.L.,Gould,D.J.,Mellersh,C.S.: :
Glaucoma-causing <i>ADAMTS17</i> mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma. Canine Genet Epidemiol 6:5, 2019.
Pubmed reference: 31131111 . DOI: 10.1186/s40575-019-0071-6 .
2018 Oliver,J.A.C.,Rustidge,S.,Pettitt,L.,Jenkins,C.A.,Farias,F.H.G.,Giuliano,E.A.,Mellersh,C.S.: :
Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res 79:98-106, 2018.
Pubmed reference: 29287154 . DOI: 10.2460/ajvr.79.1.98 .
2017 Bedford,P.G.: :
Open-angle glaucoma in the Petit Basset Griffon Vendeen. Vet Ophthalmol 20:98-102, 2017.
Pubmed reference: 26945802 . DOI: 10.1111/vop.12369 .
2017 Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017.
Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 .
2016 Oliver,J.A.,Forman,O.P.,Pettitt,L.,Mellersh,C.S.: :
Correction: Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One 11:e0156192, 2016.
Pubmed reference: 27192202 . DOI: 10.1371/journal.pone.0156192 .
2015 Forman,O.P.,Pettitt,L.,Komáromy,A.M.,Bedford,P.,Mellersh,C.: :
A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17. PLoS One 10:e0143546, 2015.
Pubmed reference: 26683476 . DOI: 10.1371/journal.pone.0143546 .
2015 Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015.
Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 .
2015 Oliver,J.A.,Forman,O.P.,Pettitt,L.,Mellersh,C.S.: :
Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One 10:e0140436, 2015.
Pubmed reference: 26474315 . DOI: 10.1371/journal.pone.0140436 .
2015 Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015.
Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 .